马拉维人类免疫缺陷病毒感染儿童中卡波西肉瘤疱疹病毒炎性细胞因子综合征样临床表现
Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome-like Clinical Presentation in Human Immunodeficiency Virus-infected Children in Malawi.
作者信息
El-Mallawany Nader Kim, Kamiyango William, Villiera Jimmy, Peckham-Gregory Erin C, Scheurer Michael E, McAtee Casey L, Allen Carl E, Kovarik Carrie L, Frank Dale, Eason Anthony B, Caro-Vegas Carolina, Chiao Elizabeth Y, Schutze Gordon E, Ozuah Nmazuo W, Mehta Parth S, Kazembe Peter N, Dittmer Dirk P
机构信息
Baylor College of Medicine.
Texas Children's Cancer and Hematology Centers, Houston.
出版信息
Clin Infect Dis. 2019 Nov 13;69(11):2022-2025. doi: 10.1093/cid/ciz250.
Abstract
We describe 7 human immunodeficiency virus-infected Malawian children with Kaposi sarcoma who met criteria for Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome. Each presented with persistent fevers, bulky lymphadenopathy, massive hepatosplenomegaly, and severe cytopenias. Plasma analyses were performed in 2 patients, both demonstrating extreme elevations of KSHV viral load and interleukin 6.
摘要
我们描述了7名感染人类免疫缺陷病毒的马拉维儿童，他们患有卡波西肉瘤，符合卡波西肉瘤疱疹病毒（KSHV）炎性细胞因子综合征的标准。每名儿童均表现为持续发热、巨大淋巴结病、严重肝脾肿大和严重血细胞减少。对2名患者进行了血浆分析，结果均显示KSHV病毒载量和白细胞介素6极度升高。
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