Department of Food Science, The University of Tennessee, Knoxville, TN, USA.
Plant Foods Hum Nutr. 2019 Sep;74(3):307-315. doi: 10.1007/s11130-019-00736-8.
Sorghum contains phenolic compounds with reported biological activities. The objective was to evaluate the ability of sorghum phenolic extract to inhibit inflammasomes in THP-1 human macrophages. THP-1 human macrophages was pre-treated with sorghum phenolics and the inflammasome was activated by lipopolysaccharide and adenosine triphosphate treatment. Treatment of macrophages with 50 μg sorghum extract/mL reduced IL-1β and IL-18 secretion by 59.7 and 32.0%, respectively, associated with caspase-1 activity reduction. Moreover, the production of intracellular reactive oxygen species was reduced. Our data showed the potential role of sorghum phenolics in diseases associated with aberrant inflammasomes activation.
高粱含有具有报道的生物活性的酚类化合物。本研究的目的是评估高粱酚提取物抑制人 THP-1 巨噬细胞中炎症小体的能力。用高粱酚预处理 THP-1 人巨噬细胞，用脂多糖和三磷酸腺苷处理激活炎症小体。50μg/ml 高粱提取物处理巨噬细胞后，分别减少了 59.7%和 32.0%的 IL-1β和 IL-18 分泌，与 caspase-1 活性降低有关。此外，细胞内活性氧的产生减少。我们的数据表明，高粱酚类化合物在与炎症小体异常激活相关的疾病中具有潜在作用。
