非洲动物中戊型肝炎病毒感染的流行病学：系统评价和荟萃分析方案。

Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis protocol.

机构信息

Department of Virology, Centre Pasteur of Cameroon, 451 Rue 2005, P.O. Box 1274, Yaoundé, Cameroon.

Department of Biology and Animal Physiology, Faculty of Sciences, University of Yaoundé I, P.O. Box 337, Yaoundé, Cameroon.

出版信息

Syst Rev. 2019 May 20;8(1):120. doi: 10.1186/s13643-019-1038-0.

DOI:10.1186/s13643-019-1038-0

PMID:31109366

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6528234/

Abstract

BACKGROUND

Hepatitis E virus (HEV) is one of the major causes of acute hepatitis in humans worldwide with a case-fatality rate of 1-4% in the general population that might reach 30% in pregnant women. In the past decade in Africa, studies have shown that HEV infects not only humans but also animals. A systematic review summarizing the epidemiological data of HEV has been only performed in humans residing in Africa. We will perform this systematic review and meta-analysis to assess the prevalence of HEV infection in animal species in Africa.

METHODS

This review will include cross-sectional studies among different animal species that reported the prevalence of HEV in Africa. We will consider published and unpublished studies from January 1, 2000 to present. A comprehensive search of PubMed, Excerpta Medica, African Journals Online, and Africa Index Medicus will be conducted to identify all relevant articles. Reference lists of eligible items and relevant articles will be reviewed. The funnel plots and the Egger test will be used to assess the publication bias. Study-specific estimates will be aggregated using a DerSimonian and Laird random-effects meta-analysis model to obtain an overall summary estimate of HEV prevalence across studies. The heterogeneity of the studies will be evaluated by the χ2 test on the Cochran's Q test. The results will be presented by animal species.

DISCUSSION

HEV-infected animals are likely to transmit this virus to humans in Africa, as studies have already shown in developed countries. This systematic review and meta-analysis will provide a clear picture of the epidemiology of HEV in animals in Africa, to better understand this infection and to respond adequately to the epidemic challenges that often afflict Africa.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO, CRD42018087684 .

摘要

背景

戊型肝炎病毒（HEV）是全球人类急性肝炎的主要病因之一，普通人群的病死率为 1-4%，孕妇可达 30%。在过去十年中，非洲的研究表明，HEV 不仅感染人类，还感染动物。虽然有人对居住在非洲的人类进行了戊型肝炎病毒流行病学数据的系统综述，但尚未对非洲动物中的 HEV 感染进行系统综述和荟萃分析。我们将进行这项系统综述和荟萃分析，以评估非洲动物物种中 HEV 感染的流行率。

方法

本综述将包括报告非洲 HEV 流行率的不同动物物种的横断面研究。我们将考虑 2000 年 1 月 1 日至目前发表和未发表的研究。将全面检索 PubMed、Excerpta Medica、African Journals Online 和 Africa Index Medicus，以确定所有相关文章。将对合格项目和相关文章的参考文献进行审查。将使用漏斗图和 Egger 检验评估发表偏倚。使用 DerSimonian 和 Laird 随机效应荟萃分析模型汇总研究特异性估计值，以获得跨研究的 HEV 总体流行率综合估计值。通过 Cochran's Q 检验的 χ2 检验评估研究之间的异质性。结果将按动物种类呈现。