非洲急性呼吸道感染人群中呼吸道病毒感染的流行病学：VARIAFRICA 系统评价和荟萃分析方案。

Epidemiology of respiratory viral infections in people with acute respiratory tract infections in Africa: the VARIAFRICA systematic review and meta-analysis protocol.

机构信息

Department of Virology, Centre Pasteur of Cameroon, 451 Rue 2005, P.O. Box 1274, Yaoundé, Cameroon.

Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, 451 Rue 2005, P.O. Box 1274, Yaoundé, Cameroon.

出版信息

Syst Rev. 2019 May 20;8(1):122. doi: 10.1186/s13643-019-1037-1.

DOI:10.1186/s13643-019-1037-1

PMID:31109367

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6528219/

Abstract

INTRODUCTION

Better characterisation of the epidemiological data on respiratory viral infections among people with acute respiratory tract infection (ARTI) can help to implement efficient strategies to curb the burden of ARTI in Africa. We will conduct a systematic review and meta-analysis to determine the prevalence and factors associated with respiratory viral infection in people of all ages with ARTI residing in Africa.

METHODS

This work will include cross-sectional studies published between January 1, 2000 and December 31, 2017, without any language restriction, on populations residing in African countries. We will consider studies that reported the prevalence of respiratory viruses in people with ARTI confirmed by a polymerase chain reaction technique. We will be searching PubMed, Embase, African Journals Online, Web of Science, and Global Index Medicus. The selection of relevant studies, extraction of data, and evaluation of the quality of the articles will be carried out independently by two review authors, and the discrepancies will be resolved by consensus or intervention of a third author. The heterogeneity of the studies will be assessed using the χ test on Cochrane's Q statistic. Publication bias will be assessed by the Egger test. Studies will be pooled using a random-effect meta-analysis model. Results will be presented by age group and sub-region of Africa. Using meta-regression models, we will identify factors associated with viral infections in people with ARTI.

DISCUSSION

This systematic review and meta-analysis is based on published data and therefore does not require ethical approval. This work will serve as a basis for the development of strategies for prevention and control ARTI in Africa and will also serve to identify data gaps and guide future investigations. The final report will be published in peer-reviewed journals as a scientific article and presented in workshops, conferences, and scientific conferences.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO, CRD42018088261 .

摘要

简介

更好地描述急性呼吸道感染（ARTI）人群中呼吸道病毒感染的流行病学数据，有助于在非洲实施有效的策略来减轻 ARTI 的负担。我们将进行系统评价和荟萃分析，以确定居住在非洲的所有年龄段的 ARTI 患者中呼吸道病毒感染的流行率和相关因素。

方法

这项工作将包括 2000 年 1 月 1 日至 2017 年 12 月 31 日期间发表的，无任何语言限制的，关于居住在非洲国家的人群的横断面研究。我们将考虑报告通过聚合酶链反应技术确诊为 ARTI 的患者中呼吸道病毒流行率的研究。我们将检索 PubMed、Embase、African Journals Online、Web of Science 和 Global Index Medicus。相关研究的选择、数据提取和文章质量评估将由两名综述作者独立进行，如果存在分歧，则通过共识或第三名作者的干预来解决。使用 Cochrane 的 Q 统计量的 χ 检验评估研究的异质性。使用 Egger 检验评估发表偏倚。将使用随机效应荟萃分析模型对研究进行汇总。结果将按年龄组和非洲次区域呈现。使用 meta 回归模型，我们将确定与 ARTI 患者病毒感染相关的因素。