在非洲居住的 HIV 感染者中，主要抑郁障碍的流行率和发生率：系统评价和荟萃分析方案。

Prevalence and incidence of major depressive disorders among people living with HIV residing in Africa: a systematic review and meta-analysis protocol.

机构信息

Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, PO Box: 1274, Yaoundé, Cameroon.

School of Public Health, Faculty of Medicine, University of Paris Sud XI, Le Kremlin-Bicêtre, France.

出版信息

Syst Rev. 2018 Jan 12;7(1):6. doi: 10.1186/s13643-018-0672-2.

DOI:10.1186/s13643-018-0672-2

PMID:29329579

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5767019/

Abstract

BACKGROUND

Depression represents one of the most frequent neuro-psychiatric diseases; it seems to be more prevalent in people living with HIV compared to the general population. However, summarized data in the African setting on the topic are scarce. This systematic review and meta-analysis aims at assessing the prevalence and incidence of major depressive disorders (MDD) in HIV-infected African populations residing in Africa.

METHODS AND DESIGN

This review will include observational studies conducted among HIV-infected people residing in Africa, which have reported either the prevalence or incidence of MDD or enough data for its appraisal. Relevant records will be searched using PubMed/Medline, EMBASE, African Journals Online, and Africa Index Medicus. In addition, reference lists of eligible papers and relevant review articles will be screened. Published studies from inception Jan 1, 2000 to Dec 31, 2017 will be considered regardless of language of publication. Two review authors will independently screen, select studies, and extract data, with discrepancies resolved by consensus or arbitration by a third review author. Methodological quality of included studies will be assessed using the scale developed by Hoy and colleagues. Funnel-plots and Egger's test will be used to determine publication bias. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate. The heterogeneity will be evaluated by the χ test on Cochrane's Q statistic. Results will be presented by geographical region and antiretroviral therapy status.

DISCUSSION

This study is based on published data; therefore, ethical approval is not a requirement. The final report of this study in the form of a scientific paper will be published in a peer-reviewed journal and presented at scientific conferences. This review will help to have an overview of the burden of MDD among HIV-infected people residing in Africa.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO, CRD42017058118 .

摘要

背景

抑郁症是最常见的神经精神疾病之一；与普通人群相比，生活在 HIV 感染者中的抑郁症似乎更为普遍。然而，非洲关于该主题的综合数据却很少。本系统评价和荟萃分析旨在评估居住在非洲的 HIV 感染者中重度抑郁症（MDD）的患病率和发病率。

方法和设计

本综述将包括在非洲进行的观察性研究，这些研究报告了 MDD 的患病率或发病率，或提供了足够的数据进行评估。将使用 PubMed/Medline、EMBASE、African Journals Online 和 Africa Index Medicus 搜索相关记录。此外，还将筛选合格论文和相关综述文章的参考文献列表。从 2000 年 1 月 1 日至 2017 年 12 月 31 日出版的研究将被视为不论出版语言。两位综述作者将独立筛选、选择研究并提取数据，如有分歧则通过共识或由第三位综述作者仲裁解决。使用 Hoy 及其同事制定的量表评估纳入研究的方法学质量。漏斗图和 Egger 检验将用于确定发表偏倚。通过随机效应荟萃分析模型对研究特异性估计值进行汇总，以获得总体汇总估计值。异质性将通过 Cochrane's Q 统计量的 χ 检验进行评估。结果将按地理区域和抗逆转录病毒治疗状况进行呈现。