Kunitomi Akane, Hasegawa Yuta, Lmamura Junji, Yokomaku Yoshiyuki, Tokunaga Takashi, Miyata Yasuhiko, Iida Hiroatsu, Nagai Hirokazu
Department of Hematology, National Hospital Organization Nagoya Medical Center, Japan.
Infectious Diseases and Immunology, National Hospital Organization Nagoya Medical Center, Japan.
Intern Med. 2019 Aug 15;58(16):2387-2391. doi: 10.2169/internalmedicine.1662-18. Epub 2019 May 22.
Acute promyelocytic leukemia (APL) in human immunodeficiency virus (HIV)-infected individuals is very rare. There is currently no consensus regarding the use of anti-cancer drugs with highly active anti-retroviral therapy (ART) in these patients due to their small number. We herein report two cases of APL with HIV-infected patients. Both cases received all-trans-retinoic acid-containing chemotherapies and achieved complete remission. ART was continued throughout the treatment course. The clinical course of these cases suggests that it is preferable to perform standard chemotherapy for APL with ART if patients have an adequate performance status.
人类免疫缺陷病毒（HIV）感染个体中的急性早幼粒细胞白血病（APL）非常罕见。由于此类患者数量较少，目前对于在这些患者中联合使用抗癌药物与高效抗逆转录病毒疗法（ART）尚无共识。我们在此报告两例合并HIV感染的APL患者。两例患者均接受了含全反式维甲酸的化疗并实现完全缓解。在整个治疗过程中均持续进行ART。这些病例的临床病程表明，如果患者有足够的体能状态，对合并HIV感染的APL患者进行标准化疗并联合ART是可取的。
