溴呋喃酮通过改变肠道微生物群提高泼尼松对MRL/lpr小鼠的疗效
Alterations of the Gut Microbiota Associated With Promoting Efficacy of Prednisone by Bromofuranone in MRL/lpr Mice.
作者信息
He Zhixing, Kong Xiangyu, Shao Tiejuan, Zhang Yun, Wen Chengping
机构信息
Institute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.
出版信息
Front Microbiol. 2019 May 1;10:978. doi: 10.3389/fmicb.2019.00978. eCollection 2019.
Gut microbiota played an important role in systemic lupus erythematosus (SLE) and glucocorticoids were prone to cause alterations in gut microbiota. This study addressed the effect of bromofuranone on the treatment of SLE with prednisone, since bromofuranone could regulate gut microbiota by inhibiting the AI-2/LuxS quorum-sensing. Remarkably, bromofuranone did not alleviate lupus but promoted the efficacy of prednisone in the treatment of lupus. The alterations in the gut microbiota, including decreased , , and , and increased , were associated with prednisone treatment for SLE. In addition, the increase of , , , and was positively associated with the bromofuranone-mediated promotion for the treatment of lupus. This was the first study demonstrating that the efficacy of glucocorticoids could be affected by the interventions in gut microbiota.
肠道微生物群在系统性红斑狼疮（SLE）中起重要作用，而糖皮质激素易于引起肠道微生物群的改变。本研究探讨了溴呋喃酮对泼尼松治疗SLE的影响，因为溴呋喃酮可通过抑制AI-2/LuxS群体感应来调节肠道微生物群。值得注意的是，溴呋喃酮并未减轻狼疮，而是促进了泼尼松治疗狼疮的疗效。肠道微生物群的改变，包括 、 、 和 的减少以及 的增加，与泼尼松治疗SLE有关。此外， 、 、 和 的增加与溴呋喃酮介导的狼疮治疗促进作用呈正相关。这是第一项表明糖皮质激素疗效可受肠道微生物群干预影响的研究。 （注：原文中部分微生物群相关指标未给出具体名称，用 代替）
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