Postgraduate Program in Women's Health, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Postgraduate Program in Pediatrics and Adolescence, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Skin Res Technol. 2019 Nov;25(6):793-800. doi: 10.1111/srt.12719. Epub 2019 May 22.
The development and maturation of the skin is a process that occurs during the gestation and neonatal period. Histological skin biopsy studies are relevant to improve knowledge on the skin protective barrier during the perinatal period. The thin skin of preterm newborns is unable to maintain homeostasis, thermal regulation through the skin, and is susceptible to infections. This study systematically reviewed the evidence regarding histological thickness dimensions of the skin and its layers during the late-fetal and neonatal period.
PubMed, Scopus, BVS, and e SciELO library databases, with no limits in the period of analysis or idiom. Eligibility criteria were as follows: studies describing the thickness of the entire skin or its layers during late-fetal life or the neonatal period; human being; skin biopsy analysis; and any scientific report. Two independent reviewers screened the search and extracted the following standard data: fetal or neonatal age of assessment, biopsy site, technique used for preparation and staining of histological slides, measurement techniques, and values of skin thickness.
Fifty-nine studies were screened, and eleven were identified from other sources. We recognized six studies that met the criteria for inclusion for proper extraction. Expressive differences between sites for sampling, methods of slide preparation, and number of layers measured made the thicknesses values summarization difficult. There were no reliable dimensions reported on this tissue.
Despite the importance of studying the human skin barrier, these findings confirmed limited evidence on skin thickness dimensions obtained by histology.
皮肤的发育和成熟是一个在妊娠和新生儿期发生的过程。组织学皮肤活检研究对于提高围产期皮肤保护屏障的知识是相关的。早产儿的薄皮肤无法维持体内平衡、通过皮肤进行体温调节，并且容易感染。本研究系统地回顾了关于晚期胎儿和新生儿期皮肤及其各层厚度的证据。
使用 PubMed、Scopus、BVS 和 e SciELO 图书馆数据库，没有分析期间或语言的限制。纳入标准如下：描述整个皮肤或其各层在晚期胎儿期或新生儿期的厚度的研究；人类；皮肤活检分析；以及任何科学报告。两名独立的审查员筛选了搜索结果并提取了以下标准数据：评估的胎儿或新生儿年龄、活检部位、用于准备和染色组织学切片的技术、测量技术以及皮肤厚度值。
筛选了 59 篇研究，另外还有 11 篇来自其他来源的研究被确定符合纳入标准。我们确认了 6 项符合纳入标准的研究，这些研究可以进行适当的提取。取样部位、切片制备方法和测量的层数之间存在显著差异，使得厚度值的总结变得困难。关于这种组织，没有可靠的尺寸报告。
尽管研究人类皮肤屏障非常重要，但这些发现证实了组织学获得的皮肤厚度尺寸的证据有限。
