系统性红斑狼疮中低亲和力抗DNA抗体的检测
Detection of low avidity anti-DNA antibodies in systemic lupus erythematosus.
作者信息
Riley R L, McGrath H, Taylor R P
出版信息
Arthritis Rheum. 1979 Mar;22(3):219-25. doi: 10.1002/art.1780220303.
PMID:311203
Abstract
The binding of sonicated, radiolabeled DNA by systemic lupus erythematosus (SLE) sera was measured by a high sensitivity polyethylene glycol (PEG) precipitation assay. This method is considerably more sensitive than currently used techniques. The results suggest that a significant concentration of low avidity antibodies is present in SLE sera; however, these antibodies are not detected by conventional techniques.
摘要
通过高灵敏度聚乙二醇（PEG）沉淀试验测定系统性红斑狼疮（SLE）血清对超声处理的放射性标记DNA的结合。该方法比目前使用的技术灵敏度高得多。结果表明，SLE血清中存在大量低亲和力抗体；然而，这些抗体无法通过传统技术检测到。
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