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系统性红斑狼疮中低亲和力抗DNA抗体的检测

Detection of low avidity anti-DNA antibodies in systemic lupus erythematosus.

作者信息

Riley R L, McGrath H, Taylor R P

出版信息

Arthritis Rheum. 1979 Mar;22(3):219-25. doi: 10.1002/art.1780220303.

DOI:10.1002/art.1780220303
PMID:311203
Abstract

The binding of sonicated, radiolabeled DNA by systemic lupus erythematosus (SLE) sera was measured by a high sensitivity polyethylene glycol (PEG) precipitation assay. This method is considerably more sensitive than currently used techniques. The results suggest that a significant concentration of low avidity antibodies is present in SLE sera; however, these antibodies are not detected by conventional techniques.

摘要

通过高灵敏度聚乙二醇(PEG)沉淀试验测定系统性红斑狼疮(SLE)血清对超声处理的放射性标记DNA的结合。该方法比目前使用的技术灵敏度高得多。结果表明,SLE血清中存在大量低亲和力抗体;然而,这些抗体无法通过传统技术检测到。

相似文献

1
Detection of low avidity anti-DNA antibodies in systemic lupus erythematosus.系统性红斑狼疮中低亲和力抗DNA抗体的检测
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2
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4
The use of polyethylene glycol precipitation to detect low-avidity anti-DNA antibodies in systemic lupus erythematosus.利用聚乙二醇沉淀法检测系统性红斑狼疮中低亲和力抗DNA抗体。
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Detection of anti-dsDNA as a diagnostic tool: a prospective study in 441 non-systemic lupus erythematosus patients with anti-dsDNA antibody (anti-dsDNA).将抗双链DNA作为诊断工具的检测:对441例非系统性红斑狼疮抗双链DNA抗体(抗dsDNA)患者的前瞻性研究。
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Specificity in systemic lupus erythematosus of antibodies to double-stranded DNA measured with the polyethylene glycol precipitation assay.用聚乙二醇沉淀试验测定系统性红斑狼疮中抗双链DNA抗体的特异性。
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Detection of antibodies to DNA: a technical assessment.DNA抗体的检测:一项技术评估。
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引用本文的文献

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2
Standardization of anti-DNA antibody assays.抗 DNA 抗体检测的标准化。
Immunol Res. 2013 Jul;56(2-3):420-4. doi: 10.1007/s12026-013-8415-x.
3
[Antinuclear antibodies in diagnosis of rheumatic diseases (author's transl)].抗核抗体在风湿性疾病诊断中的应用(作者译)
Klin Wochenschr. 1981 Mar 16;59(6):287-96. doi: 10.1007/BF01478208.
4
Measurement of low avidity anti-dsDNA by the Crithidia luciliae test and the PEG assay.通过利什曼原虫检测法和聚乙二醇(PEG)检测法测定低亲和力抗双链DNA。
Clin Exp Immunol. 1982 Sep;49(3):603-10.
5
Characterization of DNA in polyethylene glycol precipitated immune complexes from sera of patients with systemic lupus erythematosus.系统性红斑狼疮患者血清中聚乙二醇沉淀免疫复合物中DNA的特征分析。
Clin Exp Immunol. 1983 Oct;54(1):169-77.
6
Quantitative analyses of complement fixation in three immune complex systems.三种免疫复合物系统中补体结合的定量分析。
Immunology. 1984 Aug;52(4):753-9.
7
Suppression of NZB/NZW murine nephritis by administration of a syngeneic monoclonal antibody to DNA. Possible role of anti-idiotypic antibodies.通过给予同基因抗DNA单克隆抗体抑制NZB/NZW小鼠肾炎。抗独特型抗体的可能作用。
J Clin Invest. 1983 Jun;71(6):1728-36. doi: 10.1172/jci110927.
8
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Ann Rheum Dis. 1985 Apr;44(4):245-51. doi: 10.1136/ard.44.4.245.
9
Low avidity antibodies to double stranded DNA in systemic lupus erythematosus: a longitudinal study of their clinical significance.系统性红斑狼疮中双链DNA低亲和力抗体:其临床意义的纵向研究
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10
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