系统性红斑狼疮中双链DNA高亲和力和低亲和力抗体的纵向研究。

A longitudinal study of high and low avidity antibodies to double-stranded DNA in systemic lupus erythematosus.

作者信息

McGrath H, Biundo J J

出版信息

Arthritis Rheum. 1985 Apr;28(4):425-30. doi: 10.1002/art.1780280411.

Abstract

The role of avidity in the pathogenicity of double-stranded DNA/anti-double-stranded DNA immune complexes in systemic lupus erythematosus (SLE) has been controversial. We used polyethylene glycol to identify low avidity antibodies and the standard Farr assay to detect high avidity antibodies against double-stranded DNA in a longitudinal study of sera from 19 patients with SLE. We found that high and low avidity antibodies to double-stranded DNA did not move independently, but instead, rose and fell in a parallel and relatively fixed manner in these patients. The mechanisms responsible for the changes in titer of anti-double-stranded DNA antibody appeared nondiscriminatory in regard to avidity. In addition, the humoral immune response in SLE depicted by these antibody measurements appeared atypical, lacking maturational features.

摘要

亲和力在系统性红斑狼疮（SLE）中双链DNA/抗双链DNA免疫复合物致病性中的作用一直存在争议。在一项对19例SLE患者血清的纵向研究中，我们使用聚乙二醇来鉴定低亲和力抗体，并采用标准Farr试验来检测抗双链DNA的高亲和力抗体。我们发现，这些患者中双链DNA的高亲和力和低亲和力抗体并非独立变化，而是以平行且相对固定的方式上升和下降。抗双链DNA抗体滴度变化的机制在亲和力方面似乎没有区别。此外，通过这些抗体测量所描绘的SLE中的体液免疫反应似乎是非典型的，缺乏成熟特征。