School of Chemistry and Chemical Engineering , Key Laboratory of the Colloid and Interface Chemistry, Ministry of Education, Shandong University , Jinan , Shandong 250099 , China.
J Am Chem Soc. 2019 Jun 12;141(23):9175-9179. doi: 10.1021/jacs.9b03806. Epub 2019 May 30.
Despite the observation of noncovalent interactions between chalcogen atoms in X-ray crystal structures, catalysis that harnesses the power of such chalcogen-chalcogen bonding interactions to produce advanced molecules remains an unresolved problem. Here, we show that a class of extraordinary chalcogen-bonding catalysts enables assembly of discrete small molecules including three β-ketoaldehydes and one indole, leading to the construction of N-heterocycles in a highly efficient manner. The strong activation ability of these rationally designed catalysts provides a general solution to the intrinsic limitations of chalcogen bonding catalysis.
尽管在 X 射线晶体结构中观察到了硫属元素原子之间的非共价相互作用，但利用这种硫属元素-硫属元素键相互作用来产生先进分子的催化作用仍然是一个未解决的问题。在这里，我们表明，一类非凡的硫属键催化剂能够组装包括三个β-酮醛和一个吲哚在内的离散小分子，从而以高效的方式构建 N-杂环。这些经过合理设计的催化剂的强大激活能力为硫属键催化作用的固有局限性提供了一个通用的解决方案。
