College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China; Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China; National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, United States of America.
Neuroimage Clin. 2019;23:101834. doi: 10.1016/j.nicl.2019.101834. Epub 2019 Apr 22.
Mild cognitive impairment (MCI) is a common neurological disorder. This study aims to investigate the modulation effect of Baduanjin (a popular mind-body exercise) on MCI. 69 patients were randomized to Baduanjin, brisk walking, or an education control group for 24 weeks. The Montreal Cognitive Assessment (MoCA) and Magnetic Resonance Imaging scans were applied at baseline and at the end of the experiment. Compared to the brisk walking and control groups, the Baduanjin group experienced significantly increased MoCA scores. Amplitude of low-frequency fluctuations (ALFF) analysis showed significantly decreased ALFF values in the right hippocampus (classic low-freqency band, 0.01-0.08 Hz) in the Baduanjin group compared to the brisk walking group and increased ALFF values in the bilateral anterior cingulate cortex (ACC, slow-5 band, 0.01-0.027 Hz) in the Baduanjin group compared to the control group. Further, ALFF value changes in the right hippocampus and bilateral ACC were significantly associated with corresponding MoCA score changes across all groups. We also found increased gray matter volume in the Baduanjin group in the right hippocampus compared to the brisk walking group and in the bilateral ACC compared to the control group. In addition, there was an increased resting state functional connectivity between the hippocampus and right angular gyrus in the Baduanjin group compared to the control group. Our results demonstrate the potential of Baduanjin for the treatment of MCI.
轻度认知障碍（MCI）是一种常见的神经障碍。本研究旨在探讨八段锦（一种流行的身心锻炼）对 MCI 的调节作用。69 名患者被随机分为八段锦组、快步走组和教育对照组，进行 24 周的干预。在基线和实验结束时，应用蒙特利尔认知评估（MoCA）和磁共振成像扫描。与快步走组和对照组相比，八段锦组的 MoCA 评分显著升高。低频振幅（ALFF）分析显示，与快步走组相比，八段锦组右侧海马体（经典低频带，0.01-0.08 Hz）的 ALFF 值显著降低，与对照组相比，双侧前扣带回（ACC，慢-5 带，0.01-0.027 Hz）的 ALFF 值显著升高。此外，右侧海马体和双侧 ACC 的 ALFF 值变化与所有组的相应 MoCA 评分变化显著相关。我们还发现，与快步走组相比，八段锦组右侧海马体和双侧 ACC 的灰质体积增加，与对照组相比，八段锦组右侧海马体和双侧 ACC 的静息状态功能连接增加。我们的研究结果表明，八段锦在治疗 MCI 方面具有潜在的应用价值。
