Section of Stress, Psychiatry and Immunology & Perinatal Psychiatry, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Department of Psychological Medicine, London, UK.
Section of Stress, Psychiatry and Immunology & Perinatal Psychiatry, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Department of Psychological Medicine, London, UK; Biological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, Brescia, Italy.
Brain Behav Immun. 2020 Mar;85:57-68. doi: 10.1016/j.bbi.2019.05.032. Epub 2019 May 23.
Perinatal psychopathologies affect more than 25% of women during and after their gestational period. These psychiatric disorders can potentially determine important biological variations in their organisms, affecting many different physiological and metabolic pathways. Of relevance, any of these changes occurring in the mother can alter the normal composition of breast milk, particularly the concentration of nutritional and inflammatory components, which play a role in child brain functioning and development. Indeed, there is evidence showing that changes in milk composition can contribute to cognitive impairments and alterations in mental abilities in children. This review aims to shed light on the unique intergenerational role played by breast milk composition, from maternal psychopathologies to child development.
围产期精神病理学影响了 25%以上的女性在妊娠期和产后期间。这些精神障碍可能会导致其体内重要的生物学变化，影响许多不同的生理和代谢途径。值得注意的是，母亲体内发生的任何这些变化都会改变母乳的正常组成，特别是营养和炎症成分的浓度，这些成分在儿童的大脑功能和发育中发挥作用。事实上，有证据表明，母乳成分的变化可能导致儿童认知障碍和智力改变。本综述旨在阐明母乳成分从母体精神病理学到儿童发育的独特的代际作用。
