Griesser H, Feller A, Lennert K, Tweedale M, Messner H A, Zalcberg J, Minden M D, Mak T W
Blood. 1986 Aug;68(2):592-4.
During the development of B and T cells, a number of genes undergo rearrangement. In this paper we have studied the structure of the T cell gamma-chain gene in primary lymphomas and cell lines derived from patients with lymphoma. Samples derived from patients with angioimmunoblastic lymphadenopathy (AIL), Lennert's lymphoma, and Hodgkin's disease were also examined. TcR gamma was rearranged in all T cell lymphomas and in some B cell lymphomas and B cell lymphoma cell lines. Rearrangement of the gamma-chain gene was also found in AIL, Lennert's lymphoma, and four of eight cases of Hodgkin's disease. These studies indicate that rearrangement of TcR gamma is a useful clonal marker but does not aid in the identification of cell lineage.
在B细胞和T细胞发育过程中，许多基因会发生重排。在本文中，我们研究了原发性淋巴瘤以及淋巴瘤患者来源的细胞系中T细胞γ链基因的结构。还检测了血管免疫母细胞性淋巴结病（AIL）、 Lennert淋巴瘤和霍奇金病患者的样本。TcRγ在所有T细胞淋巴瘤以及一些B细胞淋巴瘤和B细胞淋巴瘤细胞系中发生了重排。在AIL、Lennert淋巴瘤以及8例霍奇金病中的4例中也发现了γ链基因重排。这些研究表明，TcRγ重排是一种有用的克隆标志物，但无助于细胞谱系的鉴定。
