Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Department of Cellular and Structural Biology, University of Texas Health Science, Center, San Antonio, Texas.
J Cell Physiol. 2019 Dec;234(12):21670-21682. doi: 10.1002/jcp.28865. Epub 2019 May 27.
Cervical cancer is one of the most common cancers between women and is known as the third leading cause of female cancer related deaths annually. Its detection in early stages allows it to be a preventable and generally treatable disease. Increasing evidence revealed, a variety of internal and external factors are associated with initiation and progression of cervical cancer pathogenesis. Human papilloma virus infection is found as a major cause of cervical cancer. Other molecular and biochemical alterations as well as genetic and epigenetic changes are related cervical cancer progression. Current treatment options often have severe side effects and toxicities thus, new adjuvant agents having synergistic effects and ability to decrease different side effects and toxicities are needed. Melatonin is an indolamine compound secreted from the pineal gland which shows wide range anticancer activities. A large amount of studies indicated inhibitory effects of melatonin against various types of cancers. In addition, experimental evidence reports inhibitory effects of melatonin as an adjuvant therapy on cervical cancer by targeting a sequence of different molecular mechanisms. Herein, for first time, we summarized anticervical cancer effects of melatonin and its underlying molecular mechanisms.
宫颈癌是女性中最常见的癌症之一，每年是导致女性癌症死亡的第三大主要原因。早期发现宫颈癌可使其成为一种可预防且通常可治疗的疾病。越来越多的证据表明，多种内外因素与宫颈癌发病机制的启动和进展有关。人乳头瘤病毒感染被认为是宫颈癌的主要病因。其他分子和生化改变以及遗传和表观遗传改变与宫颈癌的进展有关。目前的治疗方案往往有严重的副作用和毒性，因此需要具有协同作用并能够降低不同副作用和毒性的新辅助剂。褪黑素是一种由松果腺分泌的吲哚胺化合物，具有广泛的抗癌活性。大量研究表明褪黑素对多种类型的癌症具有抑制作用。此外，实验证据表明，褪黑素通过靶向一系列不同的分子机制作为辅助疗法对宫颈癌具有抑制作用。在此，我们首次总结了褪黑素的抗宫颈癌作用及其潜在的分子机制。
