1 Division of Dermatology, University of Ottawa, ON, Canada.
2 Division of Dermatology, McGill University, Montréal, QC, Canada.
J Cutan Med Surg. 2019 Jul/Aug;23(4):394-412. doi: 10.1177/1203475419852048. Epub 2019 May 27.
We recently reported a steady increase in the incidence and mortality of cutaneous malignant melanoma (CMM) in Canada during 1992-2010.
The objective of this article is to examine the distribution of Canadian CMM patients at the level of provinces, cities, and forward sortation area (FSA) postal codes.
Using 3 Canadian population-based registries, we conducted an in-depth examination of the incidence and mortality trends for 72 565 Canadian CMM patients over the period 1992-2010.
We found that among 20- to 39-year-olds, the incidence of CMM in women (7.17 per 100 000 individuals) was significantly higher than in men (4.60 per 100 000 individuals per year). Women age 80 years and older had an incidence of CMM (58.46 cases per 100 000 women per year) more than 4 times greater than the national average (12.29 cases per 100 000 population per year) and a corresponding high mortality rate (20.18 deaths per 100 000 women per year), when compared with the Canadian melanoma mortality of 2.4 deaths per 100 000 per year. In other age groups men had higher incidence and corresponding melanoma mortality rates. We also studied CMM incidence by province, city, and FSA postal codes and identified several high-incidence communities that were located near the coast/waterfronts. In addition, plotting latitude measures for cities and FSAs vs CMM incidence rate confirmed the inverse relationship between geographical latitude and incidence of melanoma in Canada (slope = -0.22 ± 0.05).
This research may help develop sex-, age- and geographic region-specific recommendations to decrease the future burden of CMM in Canada.
我们最近报告称，1992 年至 2010 年间加拿大皮肤恶性黑色素瘤（CMM）的发病率和死亡率呈持续上升趋势。
本文旨在研究加拿大 CMM 患者在省级、市级和前向分类区（FSA）邮政编码层面的分布情况。
利用 3 个加拿大人群登记处，我们对 1992 年至 2010 年间 72565 名加拿大 CMM 患者的发病率和死亡率趋势进行了深入研究。
我们发现，在 20 至 39 岁人群中，女性 CMM 的发病率（7.17/100000 人）明显高于男性（4.60/100000 人/年）。80 岁及以上的女性 CMM 发病率（每年每 10 万女性 58.46 例）比全国平均水平（每年每 10 万人 12.29 例）高出 4 倍以上，相应的死亡率也很高（每年每 10 万女性 20.18 例死亡），而加拿大黑色素瘤的死亡率为每年每 10 万人 2.4 例死亡。在其他年龄组中，男性的发病率和相应的黑色素瘤死亡率更高。我们还研究了按省、市和 FSA 邮政编码划分的 CMM 发病率，并确定了一些位于沿海/海滨附近的高发社区。此外，将城市和 FSA 的纬度测量值与 CMM 发病率进行绘图，证实了加拿大黑色素瘤发病率与地理位置之间的反比关系（斜率=-0.22±0.05）。
本研究有助于制定针对性别、年龄和地理区域的具体建议，以减少加拿大未来 CMM 的负担。
