接受身体活动干预的子宫内膜癌幸存者身体活动和生活质量的变化。
Change in physical activity and quality of life in endometrial cancer survivors receiving a physical activity intervention.
机构信息
Center for Energy Balance, Department of Behavioral Science, MD Anderson Cancer Center, Cancer Prevention Building, Unit 1330, 1155 Pressler St, Houston, TX, 77030, USA.
Health Promotion & Behavioral Sciences, University of Texas School of Public Health, 1200 Pressler Street, Houston, TX, 77030, USA.
出版信息
Health Qual Life Outcomes. 2019 May 27;17(1):91. doi: 10.1186/s12955-019-1154-5.
BACKGROUND
Endometrial cancer survivors are at an increased risk of poor quality of life outcomes. Physical activity is positively associated with general quality of life in this population, however, little is known about how changes in physical activity may be associated with changes in specific aspects of quality of life. The aim of this secondary data analysis was to explore the relationships between change in physical activity and change in physical, mental, social, and other aspects of quality of life in endometrial cancer survivors receiving a physical activity intervention.
METHODS
Endometrial cancer survivors (N = 100) participated in a telephone-based physical activity intervention for six months. At baseline and post-intervention we measured physical activity via accelerometry and ecological momentary assessment, and quality of life via the Short Form Health Survey (SF-36), the Quality of Life of Adult Cancer Survivors instrument, the Brief Symptom Inventory, the Pittsburgh Sleep Quality Index, and the Perceived Stress Scale. We conducted structural equation modeling path analyses to investigate how physical activity post-intervention was associated with the quality of life measures' subscales post-intervention, adjusting for baseline levels and potentially confounding covariates.
RESULTS
Increasing physical activity was positively associated with improvements in general health (p = .044), role limitation due to physical health (p = .005), pain (p = .041), and somatic distress (p = .023). There was no evidence to indicate that change in physical activity was associated with change in other aspects of quality of life.
CONCLUSIONS
Endometrial cancer survivors are at higher risk for suffering from challenges to physical quality of life, and findings from this study suggest that increasing physical activity may alleviate some of these problems. Further research is needed to determine whether other aspects of quality of life are linked to change in physical activity.
TRIAL REGISTRATION
Trial registration number: NCT00501761 Name of registry: clinicaltrials.gov Date of registration: July 16, 2007. Date of enrollment: June 16, 2005.
背景
子宫内膜癌幸存者的生活质量较差。在这一人群中，体力活动与一般生活质量呈正相关，然而，对于体力活动的变化如何与生活质量特定方面的变化相关，人们知之甚少。本二次数据分析的目的是探讨在接受体力活动干预的子宫内膜癌幸存者中，体力活动的变化与生活质量的身体、心理、社会和其他方面的变化之间的关系。
方法
子宫内膜癌幸存者（N=100）参加了一项为期六个月的基于电话的体力活动干预。在基线和干预后，我们通过加速度计和生态瞬时评估来测量体力活动，并通过简短健康调查（SF-36）、成人癌症幸存者生活质量量表、简明症状量表、匹兹堡睡眠质量指数和感知压力量表来测量生活质量。我们进行结构方程模型路径分析，以调查干预后体力活动与干预后生活质量测量子量表之间的关系，调整基线水平和潜在的混杂协变量。
结果
体力活动的增加与一般健康（p=0.044）、因身体健康受限的角色限制（p=0.005）、疼痛（p=0.041）和躯体困扰（p=0.023）的改善呈正相关。没有证据表明体力活动的变化与生活质量的其他方面的变化有关。
结论
子宫内膜癌幸存者面临着身体质量生活挑战的更高风险，本研究的结果表明，增加体力活动可能会缓解其中一些问题。需要进一步研究以确定生活质量的其他方面是否与体力活动的变化有关。
试验注册
试验注册号：NCT00501761 注册名称：clinicaltrials.gov 注册日期：2007 年 7 月 16 日。登记日期：2005 年 6 月 16 日。
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