• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

预防儿童呼吸道合胞病毒下呼吸道疾病:展望未来十年。

Prevention of Pediatric Respiratory Syncytial Virus Lower Respiratory Tract Illness: Perspectives for the Next Decade.

机构信息

Fundacion Infant, Buenos Aires, Argentina.

出版信息

Front Immunol. 2019 May 7;10:1006. doi: 10.3389/fimmu.2019.01006. eCollection 2019.

DOI:10.3389/fimmu.2019.01006
PMID:31134078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6524688/
Abstract

The landscape of infant bronchiolitis and viral pneumonia may be altered by preventive interventions against respiratory syncytial virus under evaluation today. Pediatric wards in 2018 in developing countries may differ from those attended by future generation pediatricians who may not witness the packed emergency rooms, lack of available beds, or emergency situations that all physicians caring for children with RSV experience every year. In this review, we describe and discuss different prevention strategies under evaluation to protect pediatric patients. Then, we outline a number of potential challenges, benefits, and concerns that may result from successful interventions after licensure.

摘要

如今,评估中的呼吸道合胞病毒预防干预措施可能改变婴儿细支气管炎和病毒性肺炎的流行情况。2018 年发展中国家的儿科病房可能与未来几代儿科医生所看到的不同,他们可能不会看到挤满急诊室、缺乏可用床位或每年所有治疗 RSV 患儿的医生都会遇到的紧急情况。在这篇综述中,我们描述和讨论了正在评估中的不同保护儿科患者的预防策略。然后,我们列出了一些潜在的挑战、益处和关注,这些可能是成功干预措施获得许可后的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a017/6524688/156b07aad113/fimmu-10-01006-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a017/6524688/156b07aad113/fimmu-10-01006-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a017/6524688/156b07aad113/fimmu-10-01006-g0001.jpg

相似文献

1
Prevention of Pediatric Respiratory Syncytial Virus Lower Respiratory Tract Illness: Perspectives for the Next Decade.预防儿童呼吸道合胞病毒下呼吸道疾病:展望未来十年。
Front Immunol. 2019 May 7;10:1006. doi: 10.3389/fimmu.2019.01006. eCollection 2019.
2
Women's acceptance of two strategies for preventing respiratory syncytial virus infant bronchiolitis: maternal immunization or monoclonal antibodies for newborns.女性对预防呼吸道合胞病毒所致婴儿细支气管炎的两种策略的接受度:母体免疫或给新生儿使用单克隆抗体。
Clin Microbiol Infect. 2024 Jul;30(7):958-960. doi: 10.1016/j.cmi.2024.03.014. Epub 2024 Mar 15.
3
Acute lower respiratory infections due to respiratory syncytial virus and adenovirus among hospitalized children from Argentina.阿根廷住院儿童中由呼吸道合胞病毒和腺病毒引起的急性下呼吸道感染
Clin Diagn Virol. 1998 May 1;10(1):17-23. doi: 10.1016/s0928-0197(98)00017-8.
4
Immunological Features of Respiratory Syncytial Virus-Caused Pneumonia-Implications for Vaccine Design.呼吸道合胞病毒所致肺炎的免疫学特征——对疫苗设计的启示
Int J Mol Sci. 2017 Mar 4;18(3):556. doi: 10.3390/ijms18030556.
5
Respiratory syncytial virus infections: old challenges and new opportunities.呼吸道合胞病毒感染:旧挑战与新机遇
Pediatr Infect Dis J. 2005 Nov;24(11 Suppl):S189-96, discussion S196-7. doi: 10.1097/01.inf.0000188196.87969.9a.
6
Risk factors for admission and the role of respiratory syncytial virus-specific cytotoxic T-lymphocyte responses in children with acute bronchiolitis.急性细支气管炎患儿的入院危险因素及呼吸道合胞病毒特异性细胞毒性T淋巴细胞反应的作用。
S Afr Med J. 2003 Apr;93(4):291-4.
7
Clinical and epidemiologic features of respiratory syncytial virus.呼吸道合胞病毒的临床和流行病学特征。
Curr Top Microbiol Immunol. 2013;372:39-57. doi: 10.1007/978-3-642-38919-1_2.
8
[Respiratory syncytial virus].[呼吸道合胞病毒]
Internist (Berl). 2019 Nov;60(11):1146-1150. doi: 10.1007/s00108-019-00673-3.
9
Respiratory syncytial virus--is it preventable?呼吸道合胞病毒——它可以预防吗?
J Hosp Infect. 1995 Jun;30 Suppl:494-7. doi: 10.1016/0195-6701(95)90053-5.
10
Prevention of bronchiolitis.毛细支气管炎的预防
Paediatr Respir Rev. 2000 Sep;1(3):228-34. doi: 10.1053/prrv.2000.0053.

引用本文的文献

1
Maternal Respiratory Syncytial Virus (RSV) Vaccination: Current Status and Comparison to Monoclonal Antibodies (mAbs) for RSV Prevention in Infants and Children.孕妇呼吸道合胞病毒(RSV)疫苗接种:现状及与预防婴幼儿RSV的单克隆抗体(mAb)的比较
J Mother Child. 2025 Aug 16;29(1):93-100. doi: 10.34763/jmotherandchild.20252901.d-25-00012. eCollection 2025 Feb 1.
2
Immune correlates analysis of mRNA-1345 RSV vaccine efficacy clinical trial.mRNA-1345呼吸道合胞病毒疫苗疗效临床试验的免疫相关分析
Nat Commun. 2025 Jul 3;16(1):6118. doi: 10.1038/s41467-025-61153-x.
3
Hospitalizations for respiratory syncytial virus (RSV) in Sicily from 2008 to 2021: clinical features and predictors of severity.

本文引用的文献

1
Predictors of hospitalization for acute lower respiratory infections during the first two years of life in a population of preterm infants with bronchopulmonary dysplasia.患有支气管肺发育不良的早产婴儿群体出生后头两年急性下呼吸道感染住院治疗的预测因素。
Early Hum Dev. 2018 Dec;127:53-57. doi: 10.1016/j.earlhumdev.2018.10.003. Epub 2018 Oct 9.
2
Mortality Associated With Acute Respiratory Infections Among Children at Home.儿童在家中急性呼吸道感染的死亡率。
J Infect Dis. 2019 Jan 9;219(3):358-364. doi: 10.1093/infdis/jiy517.
3
Type I Interferon Potentiates IgA Immunity to Respiratory Syncytial Virus Infection During Infancy.
2008年至2021年西西里岛呼吸道合胞病毒(RSV)住院情况:临床特征及严重程度预测因素
Ital J Pediatr. 2025 Jul 2;51(1):205. doi: 10.1186/s13052-025-01998-6.
4
Safety and Immunogenicity of an mRNA-Based RSV Vaccine Including a 12-Month Booster in a Phase 1 Clinical Trial in Healthy Older Adults.mRNA 编码 RSV 疫苗在健康老年人中进行的 1 期临床试验中包含 12 个月的加强针的安全性和免疫原性。
J Infect Dis. 2024 Sep 23;230(3):e647-e656. doi: 10.1093/infdis/jiae081.
5
Report of the WHO technical consultation on the evaluation of respiratory syncytial virus prevention cost effectiveness in low- and middle-income countries, April 7-8, 2022.世界卫生组织关于评估中低收入国家呼吸道合胞病毒预防成本效益的技术磋商报告,2022 年 4 月 7-8 日。
Vaccine. 2023 Nov 22;41(48):7047-7059. doi: 10.1016/j.vaccine.2023.09.040. Epub 2023 Sep 28.
6
Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents.含有呼吸道合胞病毒小疏水蛋白胞外域的阳离子纳米凝胶鼻用疫苗可在啮齿动物中诱导保护性免疫。
NPJ Vaccines. 2023 Jul 24;8(1):106. doi: 10.1038/s41541-023-00700-3.
7
Responding to Higher-Than-Expected Infant Mortality Rates from Respiratory Syncytial Virus (RSV): Improving Treatment and Reporting Strategies.应对高于预期的呼吸道合胞病毒(RSV)导致的婴儿死亡率:改进治疗和报告策略。
Infect Drug Resist. 2023 Jan 27;16:595-605. doi: 10.2147/IDR.S373584. eCollection 2023.
8
Preventing Respiratory Syncytial Virus in Children in France: A Narrative Review of the Importance of a Reinforced Partnership Between Parents, Healthcare Professionals, and Public Health Authorities.法国儿童呼吸道合胞病毒的预防:关于加强家长、医疗保健专业人员和公共卫生当局之间伙伴关系重要性的叙述性综述
Infect Dis Ther. 2023 Feb;12(2):317-332. doi: 10.1007/s40121-022-00737-2. Epub 2022 Dec 15.
9
Characterisation of RSV Fusion Proteins from South African Patients with RSV Disease, 2019 to 2020.2019 至 2020 年南非呼吸道合胞病毒疾病患者中呼吸道合胞病毒融合蛋白的特征
Viruses. 2022 Oct 22;14(11):2321. doi: 10.3390/v14112321.
10
Controlled Human Infection Models To Accelerate Vaccine Development.控制人体感染模型以加速疫苗开发。
Clin Microbiol Rev. 2022 Sep 21;35(3):e0000821. doi: 10.1128/cmr.00008-21. Epub 2022 Jul 6.
I 型干扰素在婴儿期增强呼吸道合胞病毒感染的 IgA 免疫。
Sci Rep. 2018 Jul 23;8(1):11034. doi: 10.1038/s41598-018-29456-w.
4
Cytokines and CD8 T cell immunity during respiratory syncytial virus infection.呼吸道合胞病毒感染期间的细胞因子和 CD8 T 细胞免疫。
Cytokine. 2020 Sep;133:154481. doi: 10.1016/j.cyto.2018.07.012. Epub 2018 Jul 18.
5
Human Extrafollicular CD4 Th Cells Help Memory B Cells Produce Igs.人类滤泡外 CD4 T 细胞有助于记忆 B 细胞产生 Igs。
J Immunol. 2018 Sep 1;201(5):1359-1372. doi: 10.4049/jimmunol.1701217. Epub 2018 Jul 20.
6
RSV prevention in infancy and asthma in later life - Authors' reply.婴儿期呼吸道合胞病毒预防与晚年哮喘——作者回复
Lancet Respir Med. 2018 Jul;6(7):e33. doi: 10.1016/S2213-2600(18)30232-7.
7
The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.呼吸道合胞病毒疫苗领域:从墓地中吸取的教训和有前途的候选者。
Lancet Infect Dis. 2018 Oct;18(10):e295-e311. doi: 10.1016/S1473-3099(18)30292-5. Epub 2018 Jun 18.
8
Differential Responses by Human Respiratory Epithelial Cell Lines to Respiratory Syncytial Virus Reflect Distinct Patterns of Infection Control.人呼吸道上皮细胞系对呼吸道合胞病毒的反应差异反映了不同的感染控制模式。
J Virol. 2018 Jul 17;92(15). doi: 10.1128/JVI.02202-17. Print 2018 Aug 1.
9
Safety and Immunogenicity of 3 Formulations of an Investigational Respiratory Syncytial Virus Vaccine in Nonpregnant Women: Results From 2 Phase 2 Trials.在非孕妇女性中三种研究性呼吸道合胞病毒疫苗制剂的安全性和免疫原性:两项 2 期试验结果。
J Infect Dis. 2018 Apr 23;217(10):1616-1625. doi: 10.1093/infdis/jiy065.
10
Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.呼吸道合胞病毒感染的婴儿产生缺乏体细胞高频突变的有效中和抗体。
Immunity. 2018 Feb 20;48(2):339-349.e5. doi: 10.1016/j.immuni.2018.01.005. Epub 2018 Feb 3.