Department of Pediatrics, The University of Calgary, Calgary, Canada.
The Alberta Children's Hospital, #200, 233-16th Avenue NW, Calgary, AB, T2M 0H5, Canada.
World J Pediatr. 2019 Dec;15(6):521-527. doi: 10.1007/s12519-019-00269-9. Epub 2019 May 27.
Gianotti-Crosti syndrome is characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical distribution.
A PubMed search was conducted using Clinical Queries with the key terms "Gianotti-Crosti syndrome" OR "papular acrodermatitis". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. This paper is based on, but not limited to, the search results.
The eruption of Gianotti-Crosti syndrome is found predominantly on the cheeks, extensor surfaces of the extremities, and buttocks. There is a sparing of antecubital and popliteal fossae as well as palms, soles, and mucosal surfaces. Although often asymptomatic, the lesions may be mildly to moderately pruritic. Gianotti-Crosti syndrome is most common in children between 1 and 6 years of age. The Epstein-Barr virus and the hepatitis B virus are the most common pathogens associated with Gianotti-Crosti syndrome. No treatment for Gianotti-Crosti syndrome is necessary because it is self-limited. In an era of vaccine hesitancy and refusal, Gianotti-Crosti syndrome may be important to mention to parents, because it can occur and trigger alarmism.
Gianotti-Crosti syndrome is mainly a disease of early childhood, characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical distribution. With the advent of more universal vaccination against hepatitis B virus, Epstein-Barr virus has become the most common etiologic agent of Gianotti-Crosti syndrome. Few cases of post-vaccination Gianotti-Crosti syndrome have been reported. Currently, the emphasis should be placed on its self-limiting attribution.
Gianotti-Crosti 综合征的特点是急性发作，出现丘疹或丘疹水疱样疹，分布对称。
使用临床查询中的关键词“Gianotti-Crosti 综合征”或“丘疹性肢端皮炎”对 PubMed 进行了搜索。搜索策略包括荟萃分析、随机对照试验、临床试验、观察性研究和综述。本文基于但不限于搜索结果。
Gianotti-Crosti 综合征的皮疹主要出现在脸颊、四肢的伸展面和臀部。肘窝和腘窝以及手掌、脚底和黏膜表面不受累。虽然通常无症状，但皮损可能轻度至中度瘙痒。Gianotti-Crosti 综合征最常见于 1 至 6 岁的儿童。与 Gianotti-Crosti 综合征相关的最常见病原体是 Epstein-Barr 病毒和乙型肝炎病毒。Gianotti-Crosti 综合征无需治疗，因为它是自限性的。在疫苗犹豫和拒绝接种的时代，Gianotti-Crosti 综合征可能对家长很重要，因为它可能会出现并引发恐慌。
Gianotti-Crosti 综合征主要是一种儿童早期疾病，其特点是急性发作，出现丘疹或丘疹水疱样疹，分布对称。随着乙型肝炎病毒更普遍的疫苗接种，Epstein-Barr 病毒已成为 Gianotti-Crosti 综合征最常见的病因。报道的接种疫苗后 Gianotti-Crosti 综合征病例很少。目前，应强调其自限性特征。
