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汞暴露及其对生育和妊娠结局的影响。

Mercury exposure and its effects on fertility and pregnancy outcome.

机构信息

Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

出版信息

Basic Clin Pharmacol Toxicol. 2019 Oct;125(4):317-327. doi: 10.1111/bcpt.13264. Epub 2019 Aug 8.

DOI:10.1111/bcpt.13264
PMID:31136080
Abstract

Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminiferous tubules, and testicular degeneration as well as abnormal menstrual cycles. Some studies investigated spontaneous abortion and complicated fertility outcome due to occupational Hg exposure. Moreover, there is a relation between inhaled Hg vapour and reproductive outcome. This MiniReview evaluates the hypothesis that exposure to Hg may increase the risk of reduced fertility, spontaneous abortion and congenital deficits or abnormalities.

摘要

汞(Hg)是一种毒性很强的环境污染物,其危害性仍然是人们关注的重点,包括对生育能力和妊娠结局的危害。研究表明,汞可导致生殖功能受损、睾丸间质细胞和生精小管的细胞变形、睾丸退化以及月经周期异常。一些研究调查了职业性汞暴露导致的自然流产和复杂的生育结局。此外,吸入汞蒸气与生殖结局之间存在关联。本综述评估了这样一种假说,即接触汞可能会增加生育能力下降、自然流产和先天缺陷或异常的风险。

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