Norton R, Batey R, Dwyer T, MacMahon S
Br Med J (Clin Res Ed). 1987 Jul 11;295(6590):80-2. doi: 10.1136/bmj.295.6590.80.
The risks in women of cirrhosis with a likely primary alcohol aetiology were estimated for various levels of alcohol consumption in a case-control study. Data were obtained from 41 women with a first diagnosis of cirrhosis who had no evidence of non-alcohol-related cirrhosis; three matched controls were interviewed for each case. Significant increases in the risk of cirrhosis were detected at levels of consumption between 41 and 60 g daily; above this level a dose-response relation was observed. The risk of cirrhosis did not appear to be influenced by other nutritional factors or history of liver disease or use of hepatotoxic drugs. One per cent of Australian women consume more than 40 g alcohol daily, yet more than 90% of women identified with cirrhosis consumed alcohol at this level. Preventive interventions to reduce alcohol consumption in the small group of women who consume more than 40 g daily have the potential to reduce substantially the incidence of alcohol related cirrhosis.
在一项病例对照研究中，针对不同酒精摄入量水平，估算了可能由原发性酒精病因导致肝硬化的女性的风险。数据来自41名首次诊断为肝硬化且无非酒精相关肝硬化证据的女性；为每个病例访谈了三名匹配的对照。在每日摄入量为41至60克之间时，检测到肝硬化风险显著增加；高于此水平，观察到剂量反应关系。肝硬化风险似乎不受其他营养因素、肝脏疾病史或肝毒性药物使用的影响。1%的澳大利亚女性每日饮酒量超过40克，但超过90%被确诊为肝硬化的女性在此水平饮酒。对每日饮酒量超过40克的一小部分女性进行减少酒精摄入的预防性干预，有可能大幅降低酒精相关肝硬化的发病率。
