Qu Shen, Rong Ao, Niu Yun-Li, Liu Xin, Zhang Yu-Shan, Liu Chun-Yu, Bi Yan-Long
Department of Ophthalmology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai 200065, China.
Int J Ophthalmol. 2022 Sep 18;15(9):1483-1487. doi: 10.18240/ijo.2022.09.11. eCollection 2022.
To assess the reproducibility of macular perfusion parameters in non-proliferative diabetic retinopathy (NPDR) patients measured by different examiners and two different sweep modes of optical coherence tomography angiography (OCTA).
Ninety-eight (98 eyes) patients with NPDR were included in this study. All participates were performed three times using Cirrus OCTA with Angiography 3×3 mm and 6×6 mm sweep mode by two examiners. The macular foveal avascular zone (FAZ) and vessel density (VD) in the superficial retinal layer (SRL) were measured. The reproducibility of the measurements was evaluated with intraclass correlation coefficients (ICC) and coefficient of variation (CoV).
The intra-mode ICCs of Angiography 3×3 mm and 6×6 mm sweep mode were 0.957 to 0.959 and 0.964 to 0.977, respectively; and the inter-mode ICCs were 0.962 to 0.970. The intra-examiner ICCs of macular perfusion parameters were >0.950; and the inter-examiner ICCs were 0.928 to 0.969. All CoVs were <1.0%.
Cirrus OCTA can measure macular perfusion parameters in NPDR patients with excellent reproducibility. The measurements of FAZ and VD in the SRL determined by Angiography 3×3 mm and 6×6 mm sweep mode are highly consistent and both sweep modes are suitable for macular perfusion parameters measurement.
评估不同检查者使用光学相干断层扫描血管造影（OCTA）的两种不同扫描模式测量非增殖性糖尿病视网膜病变（NPDR）患者黄斑灌注参数的可重复性。
本研究纳入了98例（98只眼）NPDR患者。所有参与者由两名检查者使用Cirrus OCTA以3×3 mm和6×6 mm扫描模式进行三次检查。测量黄斑中心凹无血管区（FAZ）和视网膜浅层（SRL）的血管密度（VD）。使用组内相关系数（ICC）和变异系数（CoV）评估测量的可重复性。
3×3 mm和6×6 mm扫描模式的模式内ICC分别为0.957至0.959和0.964至0.977；模式间ICC为0.962至0.970。黄斑灌注参数的检查者内ICC>0.950；检查者间ICC为0.928至0.969。所有CoV均<1.0%。
Cirrus OCTA能够以优异的可重复性测量NPDR患者的黄斑灌注参数。3×3 mm和6×6 mm扫描模式测定的SRL中FAZ和VD的测量结果高度一致，两种扫描模式均适用于黄斑灌注参数测量。
