Institute of Biomedical Sciences, Academia Sinica, 128 Section 2 Academia Road, Nangang District, Taipei 115, Taiwan.
Molecules. 2019 May 27;24(10):2017. doi: 10.3390/molecules24102017.
Cardiovascular diseases have continued to remain a leading cause of mortality and morbidity worldwide. Poor proliferation capability of adult cardiomyocytes disables the heart from regenerating new myocardium after a myocardial ischaemia event and therefore weakens the heart in the long term, which may result in heart failure and death. Delivery of cardioprotective therapeutics soon after the event can help to protect the heart from further cell death and improve cardiac function, but delivery methods and potential side effects of these therapeutics may be an issue. Advances in nanotechnology, particularly nanoparticles for drug delivery, have enabled researchers to obtain better drug targeting capability, thus increasing the therapeutic outcome. Detailed study of nanoparticles in vivo is useful as it can provide insight for future treatments. Nanogel can help to create a more favourable environment, not only for a sustained delivery of therapeutics, but also for a better navigation of the therapeutics to the targeted sites. Finally, if the damage to the myocardium is too severe for drug treatment, nanopatch can help to improve cardiac function and healing by becoming a platform for pluripotent stem cell-derived cardiomyocytes to grow for the purpose of cell-based regenerative therapy.
心血管疾病仍然是全球范围内导致死亡和发病的主要原因。成体心肌细胞增殖能力差，使得心肌缺血事件后心脏无法再生新的心肌，从而导致心脏长期衰弱，导致心力衰竭和死亡。在事件发生后尽快输送心脏保护治疗药物有助于保护心脏免受进一步的细胞死亡，并改善心脏功能，但这些治疗药物的输送方法和潜在副作用可能是一个问题。纳米技术的进步，特别是用于药物输送的纳米颗粒，使研究人员能够获得更好的药物靶向能力，从而提高治疗效果。详细研究体内的纳米颗粒很有用，因为它可以为未来的治疗提供见解。纳米凝胶有助于创造更有利的环境，不仅可以持续输送治疗药物，还可以更好地将治疗药物导航到靶向部位。最后，如果心肌损伤过于严重，无法进行药物治疗，纳米贴可以帮助改善心脏功能和愈合，成为多能干细胞衍生的心肌细胞生长的平台，用于基于细胞的再生治疗。
