Levin H S, Grossman R G, Rose J E, Teasdale G
J Neurosurg. 1979 Apr;50(4):412-22. doi: 10.3171/jns.1979.50.4.0412.
Long-term recovery from severe closed head injury was investigated in predominantly young adults whose Glasgow Coma score was 8 or less at the time of admission. Of the 27 patients studied (median follow-up interval of 1 year), 10 attained a good recovery, 12 were moderately disabled, and five were severely disabled. In contrast to previous studies suggesting that intellectual ability after severe closed head injury eventually recovers to a normal level, our findings showed that residual intellectual level, memory storage and retrieval, linguistic deficit, and personal social adjustment corresponded to overall outcome. All severely disabled patients and several moderately disabled patients exhibited unequivocal cognitive and emotional sequelae after long follow-up intervals. Analysis of persistent neuropsychological deficit in relation to neurological indices of acute injury severity demonstrated the prognostic significance of oculovestibular deficit.
对入院时格拉斯哥昏迷评分在8分及以下的主要为年轻成年人的严重闭合性颅脑损伤患者的长期恢复情况进行了调查。在研究的27例患者中（中位随访间隔为1年），10例恢复良好，12例有中度残疾，5例有重度残疾。与之前表明严重闭合性颅脑损伤后智力最终会恢复到正常水平的研究不同，我们的研究结果显示，残余智力水平、记忆存储与提取、语言缺陷以及个人社交适应情况与总体结果相符。所有重度残疾患者以及部分中度残疾患者在长时间随访后均表现出明确的认知和情感后遗症。对与急性损伤严重程度的神经学指标相关的持续性神经心理学缺陷进行分析后发现，眼前庭缺陷具有预后意义。
