Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
BMC Pharmacol Toxicol. 2019 May 28;20(1):33. doi: 10.1186/s40360-019-0309-7.
Antibiotic-resistant pathogens are an emerging threat in this century. Epinecidin-1 is a multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides) has been shown to have extensive potentials as an alternative for current antibiotics. Due to the huge costs for the study and the production of a new drug, if an antimicrobial peptide has other beneficial functions in addition to antimicrobial activities, it would be preferred.
In this study, properties and applications of Epinecidin-1 were investigated and addressed comprehensively. To achieve this, the Google Scholar search engine and three databases of PubMed, Scopus, and Web of Science were used.
Epinecidin-1 is a cationic AMP with an alpha-helical structure. Seven functional usages of this peptide have been reported in the literature including antibacterial, antifungal, antiviral, antiprotozoal, anticancer, immunomodulatory, and wound healing properties. Moreover, this peptide has high potential to be used as an active ingredient in cleaning solutions as well as application in vaccine production.
Due to significant antimicrobial activities tested on bacteria such as Staphylococcus aureus and Helicobacter pylori and also wound healing properties, Epi-1 has high potential to be considered as an important candidate for the production of new drugs and treatment of various infections including diabetic foot ulcer and peptic ulcer. Moreover, adjuvant-like properties of Epi-1 make it a suitable candidate for the studies related to an adjuvant. Other attractive properties such as anticancer effects have also been reported for this peptide which encourages further studies on this peptide.
抗生素耐药病原体是本世纪的一个新出现的威胁。海鲈抗菌肽-1 是一种多功能抗菌肽（AMP），由橙点石斑鱼（Epinephelus coioides）产生，已被证明具有广泛的潜力，可以替代目前的抗生素。由于研究和生产新药的成本巨大，如果一种抗菌肽除了具有抗菌活性外，还有其他有益的功能，那么它将更受欢迎。
本研究全面研究和探讨了海鲈抗菌肽-1 的特性和应用。为此，使用了 Google Scholar 搜索引擎和 PubMed、Scopus 和 Web of Science 三个数据库。
海鲈抗菌肽-1 是一种带有α-螺旋结构的阳离子 AMP。该肽已在文献中报道了七种功能用途，包括抗菌、抗真菌、抗病毒、抗原生动物、抗癌、免疫调节和伤口愈合特性。此外，该肽具有很高的潜力，可以用作清洁剂中的活性成分，也可以用于疫苗生产。
由于对金黄色葡萄球菌和幽门螺杆菌等细菌的显著抗菌活性以及伤口愈合特性，Epi-1 很有潜力被认为是生产新药和治疗各种感染（包括糖尿病足溃疡和消化性溃疡）的重要候选物。此外，Epi-1 的佐剂样特性使其成为与佐剂相关研究的合适候选物。该肽还具有抗癌作用等其他有吸引力的特性，这鼓励了对该肽的进一步研究。
