Division of Rheumatology, Department of Medicine, University of Alabama at Birmingham, FOT 827, 510 20th St S, Birmingham, AL, 35233, USA.
Department of Medicine, New York City Health Hospitals, Queens, Icahn School of Medicine at Mount Sinai, New York, USA.
Rheumatol Int. 2019 Jul;39(7):1279-1284. doi: 10.1007/s00296-019-04331-7. Epub 2019 May 28.
Granulomatosis with polyangiitis (GPA) commonly presents with glomerulonephritis and inflammation of upper and lower respiratory tracts. It can also involve other organs including those of the urinary tract. The involvement of the urethra is very rarely reported. We present a case of GPA in a patient who had recurrent urinary tract infections and an acute bladder outlet obstruction due to a urethral thickening by GPA. In this report, we discuss urethral involvement with GPA. The incidence of such involvement, as with other urinary tract organs, might be underestimated. It can affect both sexes, with male predominance, and can occur at any age. It responds to standard GPA medical treatment but may require surgical intervention. Rheumatologists should be aware of this limited form of GPA as early recognition and treatment can decrease the risk of complications.
肉芽肿性多血管炎（GPA）常表现为肾小球肾炎和上、下呼吸道炎症。它还可能涉及其他器官，包括泌尿系统。尿道受累的情况非常罕见。我们报告了一例 GPA 患者，该患者因 GPA 导致尿道增厚而反复发生尿路感染和急性膀胱出口梗阻。在本报告中，我们讨论了 GPA 引起的尿道受累。这种受累的发生率，以及其他泌尿系统器官的受累，可能被低估了。它可以影响两性，以男性为主，并且可以发生在任何年龄。它对 GPA 的标准治疗有反应，但可能需要手术干预。风湿病学家应该意识到这种有限形式的 GPA，因为早期识别和治疗可以降低并发症的风险。
