Mohanty Namita, San Thinn, Bell Stephen, Jalla Rasmita, Williams James, Fordjour Isaac, Siddiquee Naomi, Gavrilova-Jordan Larisa, Carbone Laura, Elam Rachel
Division of General Internal Medicine, Department of Medicine, Medical College of Georgia, Augusta University, 1120 15 Street, Augusta, GA 30912, USA.
Deparment of Medicine, Medical College of Georgia, Augusta University, 1120 15 Street, Augusta, GA 30912, USA.
Case Rep Womens Health. 2023 Mar 15;37:e00498. doi: 10.1016/j.crwh.2023.e00498. eCollection 2023 Mar.
Granulomatosis with polyangiitis (GPA) is a type of vasculitis in which granulomas deposit in small and medium-size vessels causing inflammation. It frequently affects the respiratory tract, both upper and lower tracts. Glomerulonephritis commonly occurs as well, and other systems can be affected such as the integumentary system and peripheral nervous system. Rarely, urogenital signs and symptoms are present. This report describes a case of a 19-year-old woman who presented with lower urinary tract symptoms and a urethral mass and was subsequently diagnosed with GPA. She responded well to treatment with corticosteroids, rituximab, and avacopan. This case highlights the importance of considering alternative diagnoses when a young woman presents with refractory urinary symptoms. It also highlights fertility issues relative to treatment of GPA that are of interest to the practicing obstetrician/gynecologist.
肉芽肿性多血管炎（GPA）是一种血管炎，其中肉芽肿沉积在中小血管中导致炎症。它经常影响呼吸道，包括上呼吸道和下呼吸道。肾小球肾炎也很常见，其他系统如皮肤系统和周围神经系统也可能受到影响。很少出现泌尿生殖系统的体征和症状。本报告描述了一例19岁女性病例，该患者出现下尿路症状和尿道肿物，随后被诊断为GPA。她对皮质类固醇、利妥昔单抗和阿伐可潘治疗反应良好。该病例强调了年轻女性出现难治性泌尿系统症状时考虑其他诊断的重要性。它还强调了与GPA治疗相关的生育问题，这是执业妇产科医生感兴趣的。
