第七届世界口腔医学研讨会：口腔鳞状细胞癌中长链非编码 RNA 差异表达的临床证据：范围综述。
World Workshop on Oral Medicine VII: Clinical evidence of differential expression of lncRNAs in oral squamous cell carcinoma: A scoping review.
机构信息
Department of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin, Turin, Italy.
Department of Stomatology, Division of Oral Medicine, Medical University of South Carolina, Charleston, SC, USA.
出版信息
Oral Dis. 2019 Jun;25 Suppl 1(Suppl 1):88-101. doi: 10.1111/odi.13076.
BACKGROUND
Long non-coding RNAs (lncRNAs) have important roles in regulating gene expression pertaining to cell proliferation, survival, migration and genomic stability. Dysregulated expression of lncRNAs is implicated in cancer initiation, progression and metastasis.
OBJECTIVES
To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression of lncRNAs in oral/tongue squamous cell carcinoma.
METHODS
PubMed, Scopus and Web of Science were used as search engines. Clinical, full-length, English language studies were included. PRISMA-ScR protocol was used to evaluate and present results. The present scoping review summarizes relationships of the differential expression of lncRNAs with the presence of tumour and with clinicopathological features including survival.
RESULTS
Almost half of the investigated transcripts have been explored in more than one study, yet not always with consistent results. The collected data were also compared to the limited studies investigating oral epithelial dysplasia. Data are not easily comparable, first because of different methods used to define what differential expression is, and second because only a limited number of studies performed multivariate analyses to identify clinicopathological features associated with the differentially expressed lncRNAs.
CONCLUSIONS
Standard methods and more appropriate data analyses are needed in order to achieve reliable results from future studies.
背景
长链非编码 RNA（lncRNAs）在调节与细胞增殖、存活、迁移和基因组稳定性相关的基因表达方面发挥着重要作用。lncRNAs 的表达失调与癌症的发生、进展和转移有关。
目的
探索、绘制和总结临床研究中关于口腔/舌鳞状细胞癌中 lncRNAs 差异表达的证据程度。
方法
使用 PubMed、Scopus 和 Web of Science 作为搜索引擎。纳入临床、全长、英文语言研究。使用 PRISMA-ScR 方案评估和呈现结果。本范围综述总结了 lncRNAs 差异表达与肿瘤存在以及与临床病理特征（包括生存）的关系。
结果
几乎一半的研究转录本已经在一项以上的研究中进行了探讨，但结果并不总是一致。收集的数据还与有限的研究口腔上皮异型增生进行了比较。数据不容易比较，首先是因为用于定义差异表达的方法不同，其次是因为只有少数研究进行了多变量分析以确定与差异表达 lncRNAs 相关的临床病理特征。
结论
为了从未来的研究中获得可靠的结果，需要使用标准方法和更适当的数据分析。
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