长链非编码RNA LINC00673的过表达与舌鳞状细胞癌的不良预后相关，并促进其侵袭和转移。

Overexpression long non-coding RNA LINC00673 is associated with poor prognosis and promotes invasion and metastasis in tongue squamous cell carcinoma.

作者信息

Yu Jianjun, Liu Yan, Gong Zhaojian, Zhang Shanshan, Guo Can, Li Xiayu, Tang Yanyan, Yang Liting, He Yi, Wei Fang, Wang Yumin, Liao Qianjin, Zhang Wenling, Li Xiaoling, Li Yong, Li Guiyuan, Xiong Wei, Zeng Zhaoyang

机构信息

Department of Head and Neck Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Cancer Research Institute, Central South University, Changsha, Hunan, China.

出版信息

Oncotarget. 2017 Mar 7;8(10):16621-16632. doi: 10.18632/oncotarget.14200.

Long non-coding RNAs (lncRNAs) associated with the tumorigenesis of human cancers. However, the relevance of lncRNAs in tongue squamous cell carcinoma (TSCC) is still unclear. To discover novel TSCC-related lncRNAs, we analyzed the lncRNA expression patterns in two sets of TSCC gene expression profile data, and found that long intergenic non-coding RNA 673 (LINC00673) was significantly upregulated in TSCC samples. Then we examined LINC00673 expression in 202 TSCC tissue specimens, LINC00673 is highly expressed in a significant proportion of human TSCC biopsies and correlates with poor prognosis. Knockdown LINC00673 significantly inhibited the cell invasion and migration capability in TSCC cells. Our findings suggest that LINC00673 may play an essential role in TSCC progression and might serve as a potential biomarker for early detection and prognosis prediction of TSCC.

长链非编码RNA（lncRNAs）与人类癌症的发生相关。然而，lncRNAs在舌鳞状细胞癌（TSCC）中的相关性仍不清楚。为了发现新的与TSCC相关的lncRNAs，我们分析了两组TSCC基因表达谱数据中的lncRNA表达模式，发现长链基因间非编码RNA 673（LINC00673）在TSCC样本中显著上调。然后我们检测了202例TSCC组织标本中LINC00673的表达，LINC00673在相当比例的人类TSCC活检组织中高表达，且与预后不良相关。敲低LINC00673显著抑制了TSCC细胞的侵袭和迁移能力。我们的研究结果表明，LINC00673可能在TSCC进展中起重要作用，并可能作为TSCC早期检测和预后预测的潜在生物标志物。