对单核细胞增生李斯特菌的有效保护以及对李斯特菌抗原的迟发型超敏反应取决于特定的L3T4 +和Lyt 2 + T细胞之间的协作。
Effective protection against Listeria monocytogenes and delayed-type hypersensitivity to listerial antigens depend on cooperation between specific L3T4+ and Lyt 2+ T cells.
作者信息
Kaufmann S H, Hug E, Väth U, Müller I
出版信息
Infect Immun. 1985 Apr;48(1):263-6. doi: 10.1128/iai.48.1.263-266.1985.
Abstract
Selected L3T4- and Lyt 2- T-cell subpopulations from Listeria monocytogenes-infected mice were transferred into syngenic recipients, and their capacity to adoptively mediate protection against L. monocytogenes and delayed-type hypersensitivity to listerial antigens was determined. Both functions were markedly reduced by pretreatment of cells with either anti-L3T4 or anti-Lyt 2.2 antibodies plus complement, but they could be restored by admixture of the two selected T-cell subsets. Thus, after systemic cell transfer effective protection against L. monocytogenes and delayed-type hypersensitivity to listerial antigens depend on cooperation between specific L3T4+ and Lyt 2+ T cells.
摘要
从感染单核细胞增生李斯特菌的小鼠中选取L3T4和Lyt 2 T细胞亚群，将其转移至同基因受体小鼠体内，并测定它们过继介导抗单核细胞增生李斯特菌保护作用及对李斯特菌抗原迟发型超敏反应的能力。用抗L3T4或抗Lyt 2.2抗体加补体预处理细胞后，这两种功能均显著降低，但将两个选定的T细胞亚群混合可使其恢复。因此，全身细胞转移后，对单核细胞增生李斯特菌的有效保护作用及对李斯特菌抗原的迟发型超敏反应取决于特定的L3T4⁺和Lyt 2⁺ T细胞之间的协作。
相似文献
1
Effective protection against Listeria monocytogenes and delayed-type hypersensitivity to listerial antigens depend on cooperation between specific L3T4+ and Lyt 2+ T cells.对单核细胞增生李斯特菌的有效保护以及对李斯特菌抗原的迟发型超敏反应取决于特定的L3T4 +和Lyt 2 + T细胞之间的协作。
Infect Immun. 1985 Apr;48(1):263-6. doi: 10.1128/iai.48.1.263-266.1985.
2
Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens.特定的Lyt 123细胞参与对单核细胞增生李斯特菌的防御以及对李斯特菌抗原的迟发型超敏反应。
J Exp Med. 1979 Oct 1;150(4):1033-8. doi: 10.1084/jem.150.4.1033.
3
T-cell subsets in delayed-type hypersensitivity, protection, and granuloma formation in primary and secondary Listeria infection in mice: superior role of Lyt-2+ cells in acquired immunity.小鼠原发性和继发性李斯特菌感染中迟发型超敏反应、保护性免疫及肉芽肿形成过程中的T细胞亚群：Lyt-2⁺细胞在获得性免疫中的优势作用
Infect Immun. 1988 Aug;56(8):1920-5. doi: 10.1128/iai.56.8.1920-1925.1988.
4
Effects of purified anti-Lyt-2 mAb treatment on murine listeriosis: comparative roles of Lyt-2+ and L3T4+ cells in resistance to primary and secondary infection, delayed-type hypersensitivity and adoptive transfer of resistance.纯化的抗Lyt-2单克隆抗体治疗对小鼠李斯特菌病的影响：Lyt-2⁺和L3T4⁺细胞在抵抗原发性和继发性感染、迟发型超敏反应及抗性的过继转移中的比较作用
Immunology. 1990 Sep;71(1):107-12.
5
6
Regulatory interactions between macrophages and T-cell subsets in Listeria monocytogenes-specific T-cell activation.单核细胞增生李斯特菌特异性T细胞激活过程中巨噬细胞与T细胞亚群之间的调节相互作用。
Infect Immun. 1982 Dec;38(3):907-13. doi: 10.1128/iai.38.3.907-913.1982.
7
8
Biological functions of t cell lines with specificity for the intracellular bacterium Listeria monocytogenes in vitro and in vivo.对细胞内细菌单核细胞增生李斯特菌具有特异性的T细胞系在体外和体内的生物学功能。
J Exp Med. 1982 Jun 1;155(6):1754-65. doi: 10.1084/jem.155.6.1754.
9
Impact of genetically regulated T cell proliferation on acquired resistance to Listeria monocytogenes.基因调控的T细胞增殖对单核细胞增生李斯特菌获得性耐药的影响。
J Immunol. 1989 Feb 1;142(3):932-9.
10
Specific lysis of Listeria monocytogenes-infected macrophages by class II-restricted L3T4+ T cells.II类限制性L3T4⁺ T细胞对单核细胞增生李斯特菌感染的巨噬细胞的特异性裂解作用。
Eur J Immunol. 1987 Feb;17(2):237-46. doi: 10.1002/eji.1830170214.
引用本文的文献
1
A BTLA-mediated bait and switch strategy permits Listeria expansion in CD8α(+) DCs to promote long-term T cell responses.一种由BTLA介导的“诱饵与转换”策略可使李斯特菌在CD8α(+)树突状细胞中扩增，从而促进长期的T细胞反应。
Cell Host Microbe. 2014 Jul 9;16(1):68-80. doi: 10.1016/j.chom.2014.05.021.
2
Pathological and immunological profiles of rat tuberculosis.大鼠结核病的病理学和免疫学特征
Int J Exp Pathol. 2004 Jun;85(3):125-34. doi: 10.1111/j.0959-9673.2004.00379.x.
3
Induction of protective immunity to Listeria monocytogenes by immunization with plasmid DNA expressing a helper T-cell epitope that replaces the class II-associated invariant chain peptide of the invariant chain.通过用表达替代恒定链的II类相关恒定链肽的辅助性T细胞表位的质粒DNA免疫来诱导对单核细胞增生李斯特菌的保护性免疫。
Infect Immun. 2002 May;70(5):2676-80. doi: 10.1128/IAI.70.5.2676-2680.2002.
4
Gut colonization of mice with actA-negative mutant of Listeria monocytogenes can stimulate a humoral mucosal immune response.用单核细胞增生李斯特菌的肌动蛋白聚合蛋白A阴性突变体对小鼠进行肠道定植，可刺激体液黏膜免疫反应。
Infect Immun. 2001 Jun;69(6):3542-9. doi: 10.1128/IAI.69.6.3542-3549.2001.
5
Listeria monocytogenes-infected hepatocytes are targets of major histocompatibility complex class Ib-restricted antilisterial cytotoxic T lymphocytes.单核细胞增生李斯特菌感染的肝细胞是主要组织相容性复合体 Ib 类限制的抗李斯特菌细胞毒性 T 淋巴细胞的靶标。
Infect Immun. 1998 Jun;66(6):2814-7. doi: 10.1128/IAI.66.6.2814-2817.1998.
6
Disruption of the cellular inflammatory response to Listeria monocytogenes infection in mice with disruptions in targeted genes.在靶向基因发生破坏的小鼠中，细胞对单核细胞增生李斯特菌感染的炎症反应受到破坏。
Infect Immun. 1998 May;66(5):2284-9. doi: 10.1128/IAI.66.5.2284-2289.1998.
7
8
Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis.重组沙门氏菌疫苗中分泌型抗原展示相对于体细胞抗原展示在诱导抗李斯特菌病保护方面具有更高的效力。
Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1458-63. doi: 10.1073/pnas.93.4.1458.
9
Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice.中性粒细胞参与小鼠对单核细胞增生李斯特菌的急性非特异性抵抗。
Infect Immun. 1993 Dec;61(12):5090-6. doi: 10.1128/iai.61.12.5090-5096.1993.
10
Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene.由于β2-微球蛋白基因缺失而缺乏CD8 + T淋巴细胞的淋巴细胞性脉络丛脑膜炎病毒感染小鼠的抗病毒免疫反应
J Virol. 1993 Jan;67(1):332-9. doi: 10.1128/JVI.67.1.332-339.1993.
本文引用的文献
1
Regulatory interactions between macrophages and T-cell subsets in Listeria monocytogenes-specific T-cell activation.单核细胞增生李斯特菌特异性T细胞激活过程中巨噬细胞与T细胞亚群之间的调节相互作用。
Infect Immun. 1982 Dec;38(3):907-13. doi: 10.1128/iai.38.3.907-913.1982.
2
The role of cell-mediated immunity in bacterial infections.细胞介导的免疫在细菌感染中的作用。
Rev Infect Dis. 1981 Nov-Dec;3(6):1221-50. doi: 10.1093/clinids/3.6.1221.
3
Non-H-2 restriction of expression of passively transferred delayed sensitivity.被动转移迟发型超敏反应表达的非H-2限制
J Exp Med. 1982 May 1;155(5):1334-43. doi: 10.1084/jem.155.5.1334.
4
Protection of mice against the intracellular bacterium Listeria monocytogenes by recombinant immune interferon.重组免疫干扰素对小鼠抗细胞内细菌单核细胞增生李斯特菌的保护作用。
Eur J Immunol. 1984 Oct;14(10):964-7. doi: 10.1002/eji.1830141019.
5
Attempts to characterize the T-cell population and lymphokine involved in the activation of macrophage oxygen metabolism in murine listeriosis.对参与鼠李斯特菌病中巨噬细胞氧代谢激活的T细胞群体和淋巴因子进行特征描述的尝试。
Cell Immunol. 1984 Oct 15;88(2):545-50. doi: 10.1016/0008-8749(84)90186-2.
6
Production of macrophage-activating and migration-inhibition factors in vitro by serologically selected and cloned Listeria monocytogenes-specific T cells of the Lyt 1+2- phenotype.通过血清学选择和克隆的Lyt 1+2-表型单核细胞增多性李斯特菌特异性T细胞在体外产生巨噬细胞激活因子和迁移抑制因子。
Infect Immun. 1984 Oct;46(1):111-5. doi: 10.1128/iai.46.1.111-115.1984.
7
8
Restriction in adoptive transfer of resistance to Listeria monocytogenes. II. Use of congenic and mutant mice show transfer to be H-2K restricted.对单核细胞增生李斯特菌抵抗力的过继转移限制。II. 同基因和突变小鼠的使用表明转移受H-2K限制。
Cell Immunol. 1983 Jun;78(2):199-205. doi: 10.1016/0008-8749(83)90274-5.
9
Restriction in adoptive transfer of resistance to Listeria monocytogenes. I. Influence of non-H-2 loci.单核细胞增多性李斯特菌抗性的过继转移限制。I. 非H-2基因座的影响。
Cell Immunol. 1983 Mar;76(2):304-10. doi: 10.1016/0008-8749(83)90373-8.
10
Interferon-gamma production by Listeria monocytogenes-specific T cells active in cellular antibacterial immunity.在细胞抗菌免疫中发挥作用的单核细胞增生李斯特菌特异性T细胞产生γ干扰素。
Eur J Immunol. 1983 Mar;13(3):265-8. doi: 10.1002/eji.1830130318.
Zotero 插件