Medical University of Lublin, Radziwillowska 11 Street, 20-080 Lublin, Poland.
Chair and Department of Hygiene, Medical University of Lublin, Radziwillowska 11 Street, 20-080 Lublin, Poland.
Medicina (Kaunas). 2019 May 28;55(6):222. doi: 10.3390/medicina55060222.
: Grain food consumption is a trigger of gluten related disorders: celiac disease, non-celiac gluten sensitivity (NCGS) and wheat allergy. They demonstrate with non-specific symptoms: bloating, abdominal discomfort, diarrhea and flatulence. Aim: The aim of the review is to summarize data about pathogenesis, symptoms and criteria of NCGS, which can be helpful for physicians. : The PubMed and Google Scholar databases were searched in January 2019 with phrases: 'non-celiac gluten sensitivity', non-celiac gluten sensitivity', non-celiac wheat gluten sensitivity', non-celiac wheat gluten sensitivity', and gluten sensitivity'. More than 1000 results were found. A total of 67 clinical trials published between 1989 and 2019 was scanned. After skimming abstracts, 66 articles were chosen for this review; including 26 clinical trials. Results: In 2015, Salerno Experts' Criteria of NCGS were published. The Salerno first step is assessing the clinical response to gluten free diet (GFD) and second is measuring the effect of reintroducing gluten after a period of treatment with GFD. Several clinical trials were based on the criteria. : Symptoms of NCGS are similar to other gluten-related diseases, irritable bowel syndrome and Crohn's disease. With Salerno Experts' Criteria of NCGS, it is possible to diagnose patients properly and give them advice about nutritional treatment.
乳糜泻、非乳糜泻麸质敏感性（NCGS）和小麦过敏。这些疾病表现为非特异性症状：腹胀、腹部不适、腹泻和胀气。目的：本文旨在总结 NCGS 的发病机制、症状和诊断标准方面的数据，为临床医生提供帮助。
2019 年 1 月，我们在 PubMed 和 Google Scholar 数据库中检索了以下短语：“非乳糜泻麸质敏感性”、“非乳糜泻麸质敏感性”、“非乳糜泻小麦麸质敏感性”、“非乳糜泻小麦麸质敏感性”和“麸质敏感性”，共检索到 1000 多项结果。共扫描了 1989 年至 2019 年发表的 67 项临床试验。在浏览摘要后，选择了 66 篇文章进行综述，其中包括 26 项临床试验。
2015 年，Salerno 专家提出了 NCGS 的诊断标准。Salerno 的第一步是评估无麸质饮食（GFD）对临床症状的反应，第二步是在 GFD 治疗一段时间后重新引入麸质，测量其对临床症状的影响。有几个临床试验基于这些标准。
NCGS 的症状与其他与麸质相关的疾病、肠易激综合征和克罗恩病相似。通过 Salerno 专家的 NCGS 诊断标准，可以正确诊断患者，并为其提供营养治疗建议。
