洋甘菊水醇提取物对博来霉素诱导的大鼠肺纤维化的影响。
Effect of Chamomile Hydroalcoholic Extract on Bleomycin-Induced Pulmonary Fibrosis in Rat.
作者信息
Hemmati Ali Asghar, Jalali Amir, Keshavarz Parastoo
机构信息
Department of Pharmacology, School of Pharmacy and Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Toxicology, School of Pharmacy and Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Tanaffos. 2018 Oct;17(4):264-271.
BACKGROUND
The aim of the present study was to investigate the effect of the Chamomile hydroalcoholic extract on bleomycin-induced pulmonary fibrosis in rat.
MATERIALS AND METHODS
Rats (N.Mari, 180-220 g) of either sex were given a single intratracheal instillation of bleomycin (7.5 IU/Kg) or the vehicle (saline). Treatment groups were given the same dose of bleomycin and then received different doses of oral chamomile hydroalcoholic extract (400, 600, 800, 1000, and 1500 mg/kg/day) for two weeks.
RESULTS
Histological and pharmacological experiments of bleomycin-treated animals showed that bleomycin could cause marked pulmonary fibrosis within two weeks. In addition, administration of Chamomile hydroalcoholic extract reduced such damages in lung tissue in a dose-dependent manner. Best results were obtained with 1500 /kg/day of Chamomile hydroalcoholic extract.
CONCLUSION
From the results of current study, it can be concluded that Chamomile hydroalcoholic extract may be able to diminish the toxic effects of bleomycin on the lung tissues. Such effect of Chamomile can be attributed to the ingredients of this plant with anti-inflammatory and anti-oxidant properties.
背景
本研究旨在探讨洋甘菊水醇提取物对博来霉素诱导的大鼠肺纤维化的影响。
材料与方法
将体重180 - 220克的雌雄大鼠经气管内单次注入博来霉素（7.5 IU/千克）或赋形剂（生理盐水）。治疗组给予相同剂量的博来霉素，然后连续两周给予不同剂量的口服洋甘菊水醇提取物（400、600、800、1000和1500毫克/千克/天）。
结果
对博来霉素处理的动物进行的组织学和药理学实验表明，博来霉素可在两周内引起明显的肺纤维化。此外，给予洋甘菊水醇提取物可剂量依赖性地减轻肺组织的此类损伤。以1500毫克/千克/天的洋甘菊水醇提取物获得最佳效果。
结论
从当前研究结果可以得出结论，洋甘菊水醇提取物可能能够减轻博来霉素对肺组织的毒性作用。洋甘菊的这种作用可归因于该植物具有抗炎和抗氧化特性的成分。
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