Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Sunnybrook Odette Cancer Centre, Toronto, ON, Canada.
Int J Behav Nutr Phys Act. 2018 Jun 7;15(1):49. doi: 10.1186/s12966-018-0686-0.
Given the high levels of sedentary time and treatment-related side effects in prostate cancer survivors (PCS), interventions targeting sedentary behavior (SED) may be more sustainable compared to physical activity (PA).
To examine the feasibility of a web-based intervention (RiseTx) for reducing SED and increasing moderate-to-vigorous physical activity (MVPA) among PCS undergoing ADT. Secondary outcomes include changes in SED, MVPA, light intensity PA, and quality of life.
Forty-six PCS were recruited from two cancer centres in Toronto, Ontario, Canada between July 2015-October 2016. PCS were given an activity tracker (Jawbone), access to the RiseTx website program, and provided with a goal of increasing walking by 3000 daily steps above baseline levels over a 12-week period. A range of support tools were progressively released to reduce SED time (e.g., self-monitoring of steps) during the five-phase program. Objective measures of SED, MVPA, and daily steps were compared across the 12-week intervention using linear mixed models.
Of the 46 PCS enrolled in the study, 42 completed the SED intervention, representing a 9% attrition rate. Measurement completion rates were 97 and 65% at immediately post-intervention and 12-week follow-up for all measures, respectively. Overall adherence was 64% for total number of logins (i.e., > 3 visits each week). Sample mean age was 73.2 ± 7.3 years, mean BMI was 28.0 ± 3.0 kg/m, mean number of months since diagnosis was 93.6 ± 71.2, and 72% had ADT administered continuously. Significant reductions of 455.4 weekly minutes of SED time were observed at post-intervention (p = .005). Significant increases of + 44.1 for weekly minutes of MVPA was observed at immediately post-intervention (p = .010). There were significant increases in step counts of + 1535 steps from baseline to post-intervention (p < .001).
RiseTx was successful in reducing SED and increasing MVPA in PCS. PCS were satisfied with the intervention and its components. Additional strategies may be needed though for maintenance of behavior change. The next step for RiseTx is to replicate these findings in a larger, randomized controlled trial that will have the potential for reducing sedentary time among PCS.
NCT03321149 (ClinicalTrials.gov Identifier).
鉴于前列腺癌幸存者（PCS）久坐时间水平较高和与治疗相关的副作用，针对久坐行为（SED）的干预措施可能比身体活动（PA）更具可持续性。
研究针对接受 ADT 的 PCS 的基于网络的干预措施（RiseTx）减少 SED 和增加中等至剧烈体力活动（MVPA）的可行性。次要结果包括 SED、MVPA、低强度体力活动（LIPA）和生活质量的变化。
2015 年 7 月至 2016 年 10 月期间，从加拿大安大略省多伦多的两个癌症中心招募了 46 名 PCS。为 PCS 提供活动追踪器（Jawbone）、访问 RiseTx 网站程序，并设定目标，即在 12 周内将每天的步数比基线水平增加 3000 步。在五个阶段的计划中，逐步发布了一系列支持工具，以减少 SED 时间（例如，自我监测步数）。使用线性混合模型比较了 12 周干预期间的 SED、MVPA 和每日步数的客观测量值。
在研究中招募的 46 名 PCS 中，有 42 名完成了 SED 干预，流失率为 9%。在立即干预后和 12 周随访时，所有测量值的测量完成率分别为 97%和 65%。总体依从性为总登录次数的 64%（即每周>3 次）。样本平均年龄为 73.2±7.3 岁，平均 BMI 为 28.0±3.0kg/m，平均诊断后时间为 93.6±71.2 个月，72%的患者连续接受 ADT 治疗。在干预后观察到每周 SED 时间减少 455.4 分钟（p=0.005）。在立即干预后观察到每周 MVPA 分钟数增加了 +44.1 分钟（p=0.010）。与基线相比，干预后步计数增加了 +1535 步（p<0.001）。
RiseTx 成功减少了 PCS 的 SED 和增加了 MVPA。PCS 对干预措施及其组成部分感到满意。不过，可能需要采取其他策略来维持行为改变。RiseTx 的下一步是在更大的随机对照试验中复制这些发现，这有可能减少 PCS 的久坐时间。
NCT03321149（ClinicalTrials.gov 标识符）。
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