转基因技术迅速杀死布基纳法索疟疾流行地区的蚊子。

Transgenic rapidly kills mosquitoes in a malaria-endemic region of Burkina Faso.

机构信息

Department of Entomology, University of Maryland, College Park, MD 20742, USA.

Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Burkina Faso.

出版信息

Science. 2019 May 31;364(6443):894-897. doi: 10.1126/science.aaw8737.

DOI:10.1126/science.aaw8737

PMID:31147521

Abstract

Malaria control efforts require implementation of new technologies that manage insecticide resistance. provides an effective, mosquito-specific delivery system for potent insect-selective toxins. A semifield trial in a MosquitoSphere (a contained, near-natural environment) in Soumousso, a region of Burkina Faso where malaria is endemic, confirmed that the expression of an insect-specific toxin (Hybrid) increased fungal lethality and the likelihood that insecticide-resistant mosquitoes would be eliminated from a site. Also, as Hybrid-expressing is effective at very low spore doses, its efficacy lasted longer than that of the unmodified Deployment of transgenic against mosquitoes could (subject to appropriate registration) be rapid, with products that could synergistically integrate with existing chemical control strategies to avert insecticide resistance.

摘要

疟疾控制工作需要实施新技术来管理杀虫剂抗性。为有效的、针对蚊子的、选择性杀虫剂提供了一个特定的输送系统。在布基纳法索疟疾流行的 Soumousso 地区的一个 MosquitoSphere（一个封闭的、接近自然的环境）中进行的半田间试验证实，表达一种昆虫特异性毒素（Hybrid）增加了真菌的致死率，并增加了具有杀虫剂抗性的蚊子从一个地点被消灭的可能性。此外，由于表达 Hybrid 的在非常低的孢子剂量下也有效，其功效持续时间比未修饰的更长。转基因对蚊子的部署（在适当的注册的前提下）可能会很快，其产品可以与现有的化学控制策略协同集成，以避免杀虫剂抗性。