Bilgo Etienne, Lovett Brian, Millogo Abel Souro, Sare Issiaka, Gnambani Edounou Jacques, Leger Raymond St, Diabaté Abdoulaye
Institut de Recherche en Sciences de la Santé, IRSS, Bobo-Dioulasso, Burkina Faso.
Institut National de Santé Publique (INSP)/Centre Muraz, Bobo-Dioulasso, Burkina Faso.
Sci Rep. 2025 Jan 16;15(1):2181. doi: 10.1038/s41598-024-83242-5.
Entomopathogenic fungi engineered to express insect-specific neurotoxins have demonstrated potential as microbial control agents against malaria mosquitoes. Currently, the primary application method is via direct contact of spores with indoor resting mosquitoes. However, many malaria-transmitting mosquitoes feed and rest outdoors. To target these, we have developed an alternative application method that exploits the lethality of transgenic fungi as a sexually transmitted mosquito disease. This approach has both a wider interdisciplinary significance and important implications for preventing mosquito-borne diseases.
经过基因工程改造以表达昆虫特异性神经毒素的昆虫病原真菌已显示出作为抗疟蚊微生物控制剂的潜力。目前，主要的应用方法是通过孢子与室内栖息蚊子的直接接触。然而，许多传播疟疾的蚊子在户外觅食和栖息。为了针对这些蚊子，我们开发了一种替代应用方法，利用转基因真菌作为一种性传播的蚊媒疾病的致死性。这种方法具有更广泛的跨学科意义，对预防蚊媒疾病具有重要意义。
