辅助性窄谱中波紫外线光疗在慢性荨麻疹治疗中的作用
Role of Adjuvant Narrow Band Ultraviolet B Phototherapy in the Treatment of Chronic Urticaria.
作者信息
Sheikh Gousia, Latif Insha, Lone Kouser Sideeq, Hassan Iffat, Jabeen Yasmeen, Keen Abid
机构信息
Department of Dermatology, STD and Leprosy, Government Medical College, Srinagar, Jammu and Kashmir, India.
Department of Social and Preventive Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India.
出版信息
Indian J Dermatol. 2019 May-Jun;64(3):250. doi: 10.4103/ijd.IJD_475_16.
BACKGROUND
Chronic urticaria is a common dermatological disorder that causes a great deal of distress in patients and affects daily life. Narrow band ultraviolet B (NBUVB) has been shown to be an effective treatment in chronic urticaria in few studies. However, the data regarding its role in chronic urticaria are limited.
AIMS AND OBJECTIVES
The aim of this study was to determine the role of NBUVB in the treatment of chronic urticaria in combination with antihistamine.
MATERIALS AND METHODS
A total of 80 patients of chronic urticaria were recruited, out of which 40 were allocated to NBUVB-loratadine group and 40 to loratadine group. Patients were assessed using urticaria activity score (UAS) at same point of time, i.e. after 4 weeks (8 sessions), 8 weeks (16 sessions) and at follow up of 4 weeks after stopping the treatment.
RESULTS
On comparing the two groups, the mean UAS was significantly lower after 8 and 16 sessions in NBUVB-loratadine group (12.03 v/s 21.43 and 3.54 v/s 17.16, respectively). The difference in reduction of UAS7 in two groups was seen to be statistically significant ( value < 0.01).
CONCLUSION
Thus we conclude that NBUVB may be useful in the treatment of chronic urticaria.
背景
慢性荨麻疹是一种常见的皮肤病，给患者带来极大痛苦并影响日常生活。少数研究表明，窄谱中波紫外线（NBUVB）对慢性荨麻疹有有效治疗作用。然而，关于其在慢性荨麻疹中作用的数据有限。
目的
本研究旨在确定NBUVB联合抗组胺药在慢性荨麻疹治疗中的作用。
材料与方法
共招募80例慢性荨麻疹患者，其中40例分配至NBUVB - 氯雷他定组，另40例分配至氯雷他定组。在相同时间点，即4周（8次照射）、8周（16次照射）以及停止治疗后4周随访时，使用荨麻疹活动评分（UAS）对患者进行评估。
结果
两组比较，NBUVB - 氯雷他定组在8次和16次照射后平均UAS显著更低（分别为12.03对21.43以及3.54对17.16）。两组UAS7降低差异具有统计学意义（P值<0.01）。
结论
因此我们得出结论，NBUVB可能对慢性荨麻疹治疗有用。
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