Yadav Sudha, Bajaj A K
Departments of Skin, Veneral Disease, and Leprosy, M.L.N. Medical College, Allahabad, UP, India.
Indian J Dermatol. 2009 Jul;54(3):275-9. doi: 10.4103/0019-5154.55641.
Chronic urticaria, a major health problem causing patient's distress, induces often physicians' dilemma while dealing with its etiology, investigations and management. Clinical approach of such cases should include apart from clinical history and physical examination laboratory investigations like routine blood test, thyroid profile, etc. as well as sometimes special test like autologous serum skin test. Management includes reassurance, avoidance of precipitating factors, treatment of underlying disorders, and non-pharmacological approach along with pharmacotherapy. First line drug therapy comprises non-sedative and sedative antihistamines, second line doxepin, nifedipine, leukotriene-inhibitors, sulfasalazine, etc. and third line cyclosporine, dapsone, colchicin, etc.
慢性荨麻疹是一个导致患者痛苦的主要健康问题，在病因、检查及治疗方面常常让医生陷入两难境地。这类病例的临床处理方法除临床病史和体格检查外，还应包括实验室检查，如血常规、甲状腺功能检查等，有时还需进行自体血清皮肤试验等特殊检查。治疗包括给予患者安慰、避免诱发因素、治疗潜在疾病，以及采用非药物治疗方法和药物治疗。一线药物治疗包括非镇静性和镇静性抗组胺药，二线药物有多虑平、硝苯地平、白三烯抑制剂、柳氮磺胺吡啶等，三线药物有环孢素、氨苯砜、秋水仙碱等。
