Schall Melissa, Iordanishvili Elene, Mauler Jörg, Oros-Peusquens Ana-Maria, Shah N Jon
Research Centre Jülich, Institute of Neuroscience and Medicine 4 (INM-4), Jülich, Germany.
Research Centre Jülich, Institute of Neuroscience and Medicine 11 (INM-11), Jülich, Germany.
J Magn Reson Imaging. 2020 Feb;51(2):514-523. doi: 10.1002/jmri.26807. Epub 2019 May 31.
Body mass index (BMI) is increasing in a large number of elderly persons. This increase in BMI is known to put one at risk for many "diseases of aging," although less is known about how a change in BMI may affect the brains of the elderly.
To investigate the relationship between BMI and quantitative water content, T , T *, and the semi-quantitative magnetization transfer ratio (MTR) of various structures in elderly brains.
Cross-sectional.
Forty-two adults (BMI range: 19.1-33.5 kg/m , age range: 58-80 years).
3T MRI (two multi-echo gradient echoes, actual flip angle imaging, magnetization prepared rapid gradient echo, fluid attenuated inversion recovery).
The 3D two-point method was used to derive (semi-)quantitative parameters in global white (WM) and gray matter (GM) and their regions as defined by the Johns Hopkins University and the Montreal Neurological Institute atlases.
Multivariate linear regression with BMI as principal regressor, corrected for the additional regressors age, gender, and glycated hemoglobin. Spearman correlation between quantitative parameters of the regions showing significant changes and the lipid spectra / C-reactive protein (CRP). Voxel-based morphometry and analysis of covariance (ANCOVA) to explore changes in the GM volume.
T increased significantly (P < 0.05) in the frontal, temporal, and parietal cortices, while the bilateral corona radiata, right superior longitudinal fasciculus, as well as the corpus callosum showed significant changes in the WM regions. T * increased significantly in the global WM and left corona radiata. Changes in MTR and the free water content did not reach significance. No significant correlation between any quantitative parameter and the lipid spectra or CRP could be identified.
These results suggest that an elevated BMI predominantly affects T in WM as well as GM structures in the elderly human brain.
3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2020;51:514-523.
大量老年人的体重指数（BMI）正在上升。已知BMI的这种增加会使人面临许多“衰老疾病”的风险，尽管关于BMI的变化如何影响老年人的大脑知之甚少。
研究BMI与老年大脑各种结构的定量含水量、T1、T2*以及半定量磁化传递率（MTR）之间的关系。
横断面研究。
42名成年人（BMI范围：19.1 - 33.5kg/m²，年龄范围：58 - 80岁）。
3T磁共振成像（两个多回波梯度回波、实际翻转角成像、磁化准备快速梯度回波、液体衰减反转恢复）。
采用三维两点法在约翰霍普金斯大学和蒙特利尔神经学研究所图谱定义的全脑白质（WM）和灰质（GM）及其区域中得出（半）定量参数。
以BMI作为主要回归变量进行多元线性回归，并对年龄、性别和糖化血红蛋白等其他回归变量进行校正。对显示有显著变化的区域的定量参数与脂质谱/ C反应蛋白（CRP）进行Spearman相关性分析。基于体素的形态测量和协方差分析（ANCOVA）以探索GM体积的变化。
额叶、颞叶和顶叶皮质的T1显著增加（P < 0.05），而双侧放射冠、右侧上纵束以及胼胝体在WM区域显示出显著变化。全脑WM和左侧放射冠的T2*显著增加。MTR和自由水含量的变化未达到显著水平。未发现任何定量参数与脂质谱或CRP之间存在显著相关性。
这些结果表明，BMI升高主要影响老年人大脑WM和GM结构中的T1。
3 技术效能：3期 《磁共振成像杂志》2020年；51:514 - 523。
