The Swedish Institute for Health Economics (IHE), Lund, Sweden.
Department of Neuromedicine and Movement Sciences, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
J Headache Pain. 2019 May 31;20(1):65. doi: 10.1186/s10194-019-1015-y.
Migraine is a disabling, chronic neurological disease leading to severe headache episodes affecting 13.2% of the Swedish population. Migraine leads to an extensive socio-economic burden in terms of healthcare costs, reduced workforce and quality of life (QoL) but studies of the health-economic consequences in a Swedish context are lacking. The objective of this study is to map the health-economic consequences of migraine in a defined patient population in terms of healthcare consumption, production loss and QoL in Sweden.
The study is based on data from a web-based survey to members in the Swedish patients' association suffering from migraine. The survey was conducted in May 2018 and included people with migraine aged 18 years or older. The survey included questions on health resource consumption, lost production resulting from migraine-related absenteeism and presenteeism, and QoL as measured by the EuroQol 5 dimensions questionnaire (EQ-5D-5 L) and the Headache Impact Test (HIT-6). The results are presented in yearly costs per patient and losses in quality adjusted life years (QALYs).
The results are based on answers from 630 individuals with migraine and are presented by number of migraine days per month. The total cost per patient and year increased with the number of migraine days per month (p < 0.001) and varied between approximately €5000 for those with less than 3 migraine days per month and €24,000 per year for those with 21-28 migraine days per month. Production loss represented the main part of the costs, approximately 80%. The average loss in QALYs per year also increased with the monthly number of migraine days (p = 0.023).
Migraine leads to significant societal costs and loss of quality of life. There appears to be an unmet need and a potential for both cost savings and QoL benefits connected with a reduction in the number of migraine days.
偏头痛是一种使人丧失能力的慢性神经系统疾病，会导致严重的头痛发作，影响瑞典总人口的 13.2%。偏头痛会导致医疗保健成本、劳动力减少和生活质量（QoL）下降等方面的巨大社会经济负担，但在瑞典语境下研究其健康经济后果的研究还很缺乏。本研究的目的是根据瑞典特定患者人群的医疗保健消费、生产损失和 QoL 来描绘偏头痛的健康经济后果。
本研究基于一项针对瑞典偏头痛患者协会成员的网络调查数据。该调查于 2018 年 5 月进行，包括年龄在 18 岁或以上的偏头痛患者。调查包括健康资源消耗、偏头痛相关缺勤和旷工导致的生产损失，以及生活质量（通过 EuroQol 5 维度问卷（EQ-5D-5L）和头痛影响测试（HIT-6）来衡量）。结果以每位患者每年的成本和质量调整生命年（QALY）损失表示。
结果基于 630 名偏头痛患者的回答，并按月偏头痛天数表示。每位患者每年的总成本随着每月偏头痛天数的增加而增加（p<0.001），每月偏头痛天数少于 3 天的患者每年费用约为 5000 欧元，每月偏头痛天数为 21-28 天的患者每年费用约为 24000 欧元。生产损失占成本的主要部分，约为 80%。每年 QALY 的平均损失也随着每月偏头痛天数的增加而增加（p=0.023）。
偏头痛会导致重大的社会成本和生活质量下降。似乎存在未满足的需求和潜在的成本节约和 QoL 改善的机会，与减少偏头痛天数有关。
