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NAD-Sirt1 和 FAD-LSD1 通路在代谢反应和组织发育中的不同作用。

Distinct Roles of the NAD-Sirt1 and FAD-LSD1 Pathways in Metabolic Response and Tissue Development.

机构信息

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

出版信息

Trends Endocrinol Metab. 2019 Jul;30(7):409-412. doi: 10.1016/j.tem.2019.04.010. Epub 2019 May 28.

DOI:10.1016/j.tem.2019.04.010
PMID:31151734
Abstract

Various nutritional signals are transduced by two epigenetic pathways: NAD-dependent sirtuin Sirt1 (NAD-Sirt1) deacetylase and flavin adenine dinucleotide-dependent lysine-specific demethylase 1 (FAD-LSD1). These pathways are controlled by dietary vitamins and nutrient-responsive hormones such as glucocorticoids and insulin, resulting in endocrine-metabolism-epigenome cooperation in adipocyte and skeletal muscle development.

摘要

各种营养信号通过两种表观遗传途径进行转导：NAD 依赖性组蛋白去乙酰化酶 Sirt1（NAD-Sirt1）和黄素腺嘌呤二核苷酸依赖性赖氨酸特异性去甲基化酶 1（FAD-LSD1）。这些途径受膳食维生素和营养响应激素（如糖皮质激素和胰岛素）的控制，导致脂肪细胞和骨骼肌发育中的内分泌-代谢-表观基因组合作。

相似文献

[1]
Distinct Roles of the NAD-Sirt1 and FAD-LSD1 Pathways in Metabolic Response and Tissue Development.

Trends Endocrinol Metab. 2019-5-28

[2]
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[3]
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[4]
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[5]
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Cell Death Dis. 2017-12-11

[6]
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[7]
SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells.

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[8]
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.

Front Immunol. 2019-6-12

[9]
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Crit Rev Eukaryot Gene Expr. 2012

[10]
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J Cell Biol. 2022-12-5

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[4]
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[5]
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[6]
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[7]
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