Yamada H, Miwa K, Yonemura Y, Tanaka S, Hasegawa K, Miyazaki I
Gan To Kagaku Ryoho. 1987 Sep;14(9):2779-82.
The prognosis for patients with unresectable gastric cancer is so poor that 50% survival time is no more than 3 months. A 58-year-old woman was admitted for advanced gastric cancer with multiple liver metastases. Preoperatively, she received hepatic arterial infusion of 75 mg/m2 of cis-platinum during abdominal angiography. As laparotomy revealed an unresectable gastric tumor of the classification H3P2N4S3, a catheter was introduced into the aorta at the level of the celiac axis via a branch of the right femoral artery and 10 mg of Mitomycin C was infused into the abdominal aorta through the catheter. Postoperative chemotherapy consisted of continuous intra-arterial infusion of 250 mg/day of 5-Fluorouracil for 14 days, followed by infusion of another 10 mg of Mitomycin C. Daily oral administration of 600 mg of tegafur was continued in the outpatient clinic. Three months after surgery, the primary and hepatic metastatic lesions had regressed by 76 and 88-98% on abdominal computed tomography and gastric fluoroscopy, respectively. The dimensions of the lesions remained unchanged for the subsequent two months, and their responses to the treatment were judged PR. Eight months after surgery, the patient is in good general condition.
无法切除的胃癌患者预后很差，其50%的生存时间不超过3个月。一名58岁女性因晚期胃癌伴多发肝转移入院。术前，她在腹部血管造影期间接受了75 mg/m²顺铂的肝动脉灌注。剖腹探查发现为H3P2N4S3分类的无法切除的胃肿瘤，通过右股动脉分支在腹腔干水平将导管插入主动脉，并通过导管向腹主动脉注入10 mg丝裂霉素C。术后化疗包括连续14天每天经动脉灌注250 mg 5-氟尿嘧啶，随后再注入10 mg丝裂霉素C。门诊继续每日口服600 mg替加氟。术后3个月，腹部计算机断层扫描和胃荧光镜检查显示，原发性和肝转移病变分别缩小了76%和88%-98%。在随后的两个月里，病变大小保持不变，其对治疗的反应判定为部分缓解（PR）。术后8个月，患者一般状况良好。
