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[顺铂、丝裂霉素C与5-氟尿嘧啶联合给药成功治疗晚期胃癌。病例报告]

[Successful treatment of advanced gastric cancer by combined cisplatinum, mitomycin C and 5-FU administration. A case report].

作者信息

Tanemura H, Kawata R, Suzuki M, Shimokawa K, Tsuya H, Ando T, Azuma S, Furuta T, Saji S, Ohashi H

出版信息

Gan To Kagaku Ryoho. 1987 Mar;14(3 Pt 1):728-31.

PMID:3103542
Abstract

A 55-year-old woman with gastric cancer underwent laparotomy and was found to have an unresectable tumor at the MC region, characterized by S3 (invasion into the pancreas), N3, P0, H0, Borrmann-II and moderately differentiated tubular adenocarcinoma. She was then treated by combined administration of cis-dichlorodiammine platinum (CDDP), mitomycin C and 5-fluorouracil (5-FU). A complete response was confirmed by upper gastrointestinal roentgenography and endoscopy. Upon reoperation 4 months after the initial laparotomy, a successful total radical gastrectomy with R2 (partially R3) lymph node dissection was performed. Histological examination of the specimens, including the stomach and lymph nodes, revealed no cancer cells in any region.

摘要

一名55岁的胃癌女性接受了剖腹手术,发现其胃中部区域有一个无法切除的肿瘤,特征为S3(侵犯胰腺)、N3、P0、H0、Borrmann-II型和中分化管状腺癌。随后她接受了顺二氯二氨铂(CDDP)、丝裂霉素C和5-氟尿嘧啶(5-FU)联合给药治疗。上消化道造影和内镜检查证实完全缓解。在初次剖腹手术后4个月再次手术时,成功进行了R2(部分为R3)淋巴结清扫的全根治性胃切除术。对包括胃和淋巴结在内的标本进行组织学检查,发现任何区域均无癌细胞。

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