Department of Neurology, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, 00029, Helsinki, Finland.
Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.
J Neurol. 2019 Sep;266(9):2216-2223. doi: 10.1007/s00415-019-09402-0. Epub 2019 May 31.
Cervical dystonia (CD) is the most common form of dystonia. The onset of CD is usually before 60 years of age and it may cause severe functional and psychosocial impairment in everyday life. Recently non-motor symptoms have been reported to occur in CD substantially affecting the quality of life.
METHODS/PATIENTS: We studied comorbidities of patients with primary focal CD in Finland based on ICD-10 codes obtained from the care registry and patient records of 937 confirmed adult isolated focal CD patients between the years 2007-2016. The retirement months and diagnosis of retirement were calculated from pension registry information. The results were compared with 3746 age and gender-matched controls.
Most prominent comorbidities with primary focal CD were depression (14%), anxiety (7%), and back pain (11%). The retirement age was significantly younger in CD patients compared to control group controls (59.0 years, 95% CI 58.5-59.5 vs. 61.7 years, 95% CI 61.6-61.9) years, p < 0.001). For dystonia patients the most common diagnoses for retirement due to sickness were dystonia (51%), depression (14%), and anxiety (8%). Patients with anxiety and depression retired earlier than other dystonia patients.
Cervical dystonia considerably reduces working ability and leads to earlier retirement. Anxiety and depression are most notable comorbidities and their co-occurrence further reduces working ability. Our results suggest that more health care resources should be administered in treatment of CD to longer maintain working ability of CD patients. Further, psychiatric comorbidities should be taken into consideration in CD treatment.
颈肌张力障碍(CD)是最常见的肌张力障碍形式。CD 的发病通常在 60 岁之前,它可能会导致日常生活中严重的功能和社会心理障碍。最近,据报道,CD 患者出现了大量非运动症状,这极大地影响了他们的生活质量。
方法/患者:我们基于 2007 年至 2016 年间从护理登记处和 937 名确诊的成年孤立性局灶性 CD 患者的病历中获得的 ICD-10 代码,研究了芬兰原发性局灶性 CD 患者的合并症。从养老金登记处信息中计算了退休月份和退休诊断。结果与 3746 名年龄和性别匹配的对照组进行了比较。
与原发性局灶性 CD 最常见的合并症是抑郁(14%)、焦虑(7%)和背痛(11%)。与对照组相比,CD 患者的退休年龄明显更早(59.0 岁,95%CI 58.5-59.5 与 61.7 岁,95%CI 61.6-61.9 岁,p<0.001)。对于因疾病退休的肌张力障碍患者,最常见的诊断是肌张力障碍(51%)、抑郁(14%)和焦虑(8%)。患有焦虑和抑郁的患者比其他肌张力障碍患者更早退休。
颈肌张力障碍大大降低了工作能力,导致提前退休。焦虑和抑郁是最明显的合并症,它们的共同发生进一步降低了工作能力。我们的研究结果表明,应该在 CD 的治疗中投入更多的医疗资源,以更长时间地保持 CD 患者的工作能力。此外,在 CD 的治疗中应考虑到精神科合并症。