Laboratory for Epigenetics, Metabolism and longevity, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany.
Laboratory for Epigenetics, Metabolism and longevity, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany; Laboratory for Metabolism and Epigenetics in Brain Aging, Institute of Neuroregeneration & Neurorehabilitation of Qingdao University, China.
Chem Phys Lipids. 2019 Aug;222:59-69. doi: 10.1016/j.chemphyslip.2019.05.005. Epub 2019 May 29.
Fat is historically associated with poor health and obesity. However, the continuous use of lipidomics and genetic studies in model organisms revealed that specific lipid profiles and signals might delay aging. In order to identify and quantify the lipid species, researchers are taking advantage of the recent developments in the area of lipidomics that is mainly done by mass spectrometry and further techniques, such as NMR spectroscopy and chromatographic separations. This review will emphasize the role of lipid composition and metabolism during aging. We review the molecular and physiological changes during the progression of aging with a special focus on the role of lipids. Interventions to modulate life span in a variety of organisms such caloric restriction, show a significant extension of their maximum life-span and a decrease in the onset of age-related diseases. In particular, the influence of dietary restriction in lipid metabolism will be a major point of this review.
脂肪一直与健康状况不佳和肥胖联系在一起。然而，脂质组学和遗传研究在模式生物中的不断应用表明，特定的脂质谱和信号可能会延缓衰老。为了鉴定和定量脂质种类，研究人员正在利用脂质组学领域的最新进展，主要通过质谱和其他技术，如 NMR 光谱和色谱分离来实现。这篇综述将强调脂质组成和代谢在衰老过程中的作用。我们综述了衰老过程中分子和生理变化，特别关注脂质的作用。各种干预措施，如热量限制，可以调节生物体的寿命，显著延长其最大寿命，并减少与年龄相关疾病的发生。特别是，饮食限制对脂质代谢的影响将是本综述的一个主要要点。
