Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Developmental Biology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.
Dev Cell. 2021 May 17;56(10):1394-1407. doi: 10.1016/j.devcel.2021.03.034. Epub 2021 Apr 22.
Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series of genetic pathways have been discovered to regulate lifespan in model organisms. Interestingly, many of these regulatory pathways are linked to lipid metabolism and lipid signaling. Lipid metabolic enzymes undergo significant changes during aging and are regulated by different longevity pathways. Lipids also actively modulate lifespan and health span as signaling molecules. In this review, we summarize recent insights into the roles of lipid metabolism and lipid signaling in aging and discuss lipid-related interventions in promoting longevity.
脂质在调节衰老和长寿方面起着至关重要的作用。在过去的几十年中，人们发现了一系列调节模型生物寿命的遗传途径。有趣的是，这些调节途径中有许多与脂质代谢和脂质信号有关。脂质代谢酶在衰老过程中发生显著变化，并受不同的长寿途径调节。脂质作为信号分子也积极调节寿命和健康跨度。在这篇综述中，我们总结了脂质代谢和脂质信号在衰老过程中的作用的最新见解，并讨论了脂质相关干预措施在促进长寿方面的应用。
