State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), No.14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, China.
State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China; Hubei Key Laboratory of Industrial Microbiology, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China.
Life Sci. 2019 Aug 15;231:116509. doi: 10.1016/j.lfs.2019.05.065. Epub 2019 May 29.
Non-coding RNAs (NcRNAs), a family of functional RNA molecules that cannot translate into proteins but control specific gene expression programs, have been shown to be implicated in various biological processes, including fatty acid metabolism. Fast-growing tumor cells rewire their fatty acid metabolic circuitry in order to meet the needs of energy storage, membrane proliferation, and the generation of signaling molecules, which is achieved by regulating a variety of key enzymes along with related signaling pathways in fatty acid metabolism. This review presents an update of our knowledge about the regulatory network of ncRNAs-specifically, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs)-in this metabolic shift and discusses the possibility of ncRNA-based therapeutics being applied to the restoration of cancer-related fatty acid metabolism.
非编码 RNA（NcRNAs）是一类不能翻译成蛋白质但能控制特定基因表达程序的功能性 RNA 分子，已被证明与多种生物过程有关，包括脂肪酸代谢。快速生长的肿瘤细胞重新调整其脂肪酸代谢电路，以满足能量储存、膜增殖和信号分子生成的需求，这是通过调节脂肪酸代谢中的各种关键酶以及相关信号通路来实现的。本综述介绍了我们对 ncRNAs（特别是 microRNAs（miRNAs）、长链非编码 RNA（lncRNAs）和环状 RNA（circRNAs））在这种代谢转变中的调控网络的最新认识，并讨论了基于 ncRNA 的治疗方法应用于恢复与癌症相关的脂肪酸代谢的可能性。
