Hedgehog 信号相关非编码 RNA 在发育和病理条件中的作用。
Role of hedgehog signaling related non-coding RNAs in developmental and pathological conditions.
机构信息
Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Biomed Pharmacother. 2022 Sep;153:113507. doi: 10.1016/j.biopha.2022.113507. Epub 2022 Aug 8.
The hedgehog (Hh) signaling pathway is an evolutionarily conserved pathway that regulates embryonic development in vertebrates. However, strong evidence suggests the role of its dysregulation in human diseases, especially cancers. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), belong to a group of human transcriptomes that do not translate into proteins. However, they can highly influence protein expression. This review will provide a comprehensive link between ncRNAs and Hh signaling pathways in different human diseases and development, providing insights into disease and cancer progression as well as emphasizing their therapeutic, prognostic, and diagnostic significance.
刺猬（Hh）信号通路是一种进化上保守的通路，它调节脊椎动物的胚胎发育。然而，强有力的证据表明其失调在人类疾病中，特别是癌症中的作用。非编码 RNA（ncRNA），包括 microRNAs（miRNAs）、长非编码 RNA（lncRNA）和 circular RNA（circRNA），属于人类转录组的一组，不翻译成蛋白质。然而，它们可以高度影响蛋白质的表达。这篇综述将提供 ncRNA 与不同人类疾病和发育中的 Hh 信号通路之间的全面联系，深入了解疾病和癌症的进展，并强调它们在治疗、预后和诊断方面的意义。
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