Cardiological Unit, Cardiovascular Disease Section, Department of Organ Transplantation, University of Bari, Italy.
Department of Biomedicine and Human Oncology, Pediatric Section, University "A.Moro" of Bari, Bari, Italy.
Vascul Pharmacol. 2019 Sep;120:106565. doi: 10.1016/j.vph.2019.106565. Epub 2019 May 29.
Non-communicable diseases represent nowadays the most common cause of death worldwide, having largely overcome infectious diseases. Among them, cardiovascular diseases constitute the majority. Given these premise, great efforts have been made by scientific societies to emphasize the fundamental role of cardiovascular prevention and risk factors control. In addition to classical cardiovascular risk factors such as smoking, arterial hypertension, hypercholesterolemia and male gender, new risk factors are emerging from international literature. Among them, uric acid is the protagonist. Several evidences show a direct role of hyperuricemia in the determinism of metabolic and vascular disorders. From the other hand, some researchers have demonstrated that uric acid is only a marker of cardiovascular damage and not a risk factor for its development. Aim of this review is to evaluate the scientific evidences on the role of uric acid in cardiovascular diseases in order to shed light on this confusing topic.
现如今，非传染性疾病是全球范围内最常见的死亡原因，在很大程度上已经超过了传染病。在这些疾病中，心血管疾病占大多数。鉴于这些前提，科学协会做出了巨大努力，强调心血管预防和危险因素控制的基本作用。除了吸烟、动脉高血压、高胆固醇血症和男性等经典心血管危险因素外，国际文献中还出现了新的危险因素。其中，尿酸是主角。有几项证据表明高尿酸血症在代谢和血管紊乱的决定因素中具有直接作用。另一方面，一些研究人员已经证明，尿酸只是心血管损害的标志物，而不是其发展的危险因素。本综述的目的是评估尿酸在心血管疾病中的作用的科学证据，以阐明这个令人困惑的课题。
