Dijon Stroke Registry (Inserm, Santé Publique France), EA7460, university hospital of Dijon, university of Burgundy and Franche-Comté, Dijon, France.
Clinical investigation center of Dijon (Inserm CIC 1432), university of Burgundy and Franche Comté, Inserm, biostatistique, biomathématique, pharmacoepidemiologie et maladies infectieuses (B2 PHI), UMR 1181, university Hospital of Dijon, Dijon, France.
Rev Neurol (Paris). 2019 Dec;175(10):619-624. doi: 10.1016/j.neurol.2019.03.003. Epub 2019 May 29.
Evidence from epidemiological studies has demonstrated that outdoor air pollution is now a well-known major problem of public health, mainly in low and middle income countries. Contrasting with myocardial infarction, there are few data on the association of air pollution and stroke.
We propose a narrative literature review of the effects and the underlying biological mechanisms of short- and long-term exposure to air pollutants on stroke risk and mortality, using the following key-words: stroke, cerebrovascular events, ischemic and haemorrhage stroke, transient ischaemic attack, mortality, air pollution and air pollutants.
Twenty-one papers were selected. Air pollution, of which whose small particulate matter are the most toxic, contributes to about one-third of the global burden of stroke. We can identify vulnerable patients with classical neuro-vascular risk factors or a prior history of stroke or transient ischemic attack or persons living in low-income countries. Biological mechanisms of this new morbid association are discussed.
Air pollution should be recognized as a silent killer inducing stroke whose mortality rates remain elevated by its role as a new modifiable neurovascular risk factor, needing public health policies.
目前已有流行病学研究证据表明，室外空气污染是一个主要的公共卫生问题，主要存在于中低收入国家。与心肌梗死不同，关于空气污染与中风之间关联的研究数据较少。
我们提出了一项关于短期和长期暴露于空气污染物对中风风险和死亡率影响及其潜在生物学机制的叙述性文献综述，使用的关键词包括：中风、脑血管事件、缺血性和出血性中风、短暂性脑缺血发作、死亡率、空气污染和空气污染物。
共选择了 21 篇论文。空气污染，其中毒性最大的是小颗粒物，约占全球中风负担的三分之一。我们可以确定易患人群为具有典型神经血管危险因素或既往中风或短暂性脑缺血发作病史或生活在低收入国家的人群。还讨论了这种新发病的病理关联的生物学机制。
空气污染应该被认为是一种沉默的杀手，可导致中风，其死亡率仍然居高不下，因为它是一个新的可改变的神经血管危险因素，需要公共卫生政策。
