Forensic DNA Typing Laboratory, Centre for Applied Molecular Biology, University of the Punjab, Lahore, Pakistan.
Forensic DNA Research Laboratory, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Int J Legal Med. 2020 Jul;134(4):1311-1312. doi: 10.1007/s00414-019-02082-5. Epub 2019 Jun 1.
In this study, the Kashmiri population was genetically screened for fifteen autosomal STRs, seventeen Y-chromosomal STRs and mitochondrial DNA control region SNPs. Autosomal STRs exhibited that D2S1338 was the most discriminatory locus with value of 0.963 whereas combine power of discrimination was 0.999999999999999. On the other hand, analysis of Y-chromosomal STRs generated 59 distinct haplotypes of which 52 were unique with haplotype diversity value of 0.99752. Mitochondrial D-loop analysis resulted that haplogroups M and U were found most prevalent with 25% each. Haplotypic data of Y-STRs was submitted to YHRD under accession number YA004153 whereas mitochondrial DNA control region (CR) sequences were submitted to EMPOP with accession number EMP00683.
在这项研究中，对克什米尔人群进行了十五个常染色体 STR、十七个 Y 染色体 STR 和线粒体 DNA 控制区 SNP 的基因筛查。常染色体 STR 显示，D2S1338 是最具区分度的基因座，其值为 0.963，而联合判别能力为 0.999999999999999。另一方面，对 Y 染色体 STR 的分析产生了 59 个不同的单倍型，其中 52 个是独特的，单倍型多样性值为 0.99752。线粒体 D-loop 分析结果表明，M 和 U 单倍群最为常见，各占 25%。Y-STR 的单倍型数据已提交给 YHRD，登录号为 YA004153，而线粒体 DNA 控制区（CR）序列已提交给 EMPOP，登录号为 EMP00683。
